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  1. No Access

    Article

    A genome-wide atlas of co-essential modules assigns function to uncharacterized genes

    A central question in the post-genomic era is how genes interact to form biological pathways. Measurements of gene dependency across hundreds of cell lines have been used to cluster genes into ‘co-essential’ p...

    Michael Wainberg, Roarke A. Kamber, Akshay Balsubramani, Robin M. Meyers… in Nature Genetics (2021)

  2. No Access

    Article

    Computational correction of copy number effect improves specificity of CRISPR–Cas9 essentiality screens in cancer cells

    CERES is a new computational method to estimate gene-dependency levels from CRISPR–Cas9 essentiality screens while accounting for copy number effects and variable sgRNA activity. Applying CERES to new genome-s...

    Robin M Meyers, Jordan G Bryan, James M McFarland, Barbara A Weir… in Nature Genetics (2017)

  3. No Access

    Article

    Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases

    An unbiased genome-wide method reveals on- and off-target DNA cleavage by TALEN and Cas9 nucleases by detecting chromosome translocation events.

    Richard L Frock, Jiazhi Hu, Robin M Meyers, Yu-Jui Ho, Erina Kii… in Nature Biotechnology (2015)