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Article
PROBER identifies proteins associated with programmable sequence-specific DNA in living cells
DNA–protein interactions mediate physiologic gene regulation and may be altered by DNA variants linked to polygenic disease. To enhance the speed and signal-to-noise ratio (SNR) in the identification and quant...
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Article
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
An unbiased genome-wide method reveals on- and off-target DNA cleavage by TALEN and Cas9 nucleases by detecting chromosome translocation events.