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  1. No Access

    Article

    Inhibition of metastasis of syngeneic murine melanoma in vivo and vasculogenesis in vitro by monoclonal antibody C11C1 targeted to domain 5 of high molecular weight kininogen

    Metastasis of malignant tumors is a major cause of morbidity and mortality. Inhibition of tumor growth in distant organs is of clinical importance. We have demonstrated that C11C1, a murine monoclonal antibody...

    Sabina T. Khan, Robin A. Pixley, Yuchuan Liu… in Cancer Immunology, Immunotherapy (2010)

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    Article

    Multiple myeloma in a murine syngeneic model:modulation of growth and angiogenesis by a monoclonal antibody to kininogen

    Multiple myeloma (MM), a B-cell malignancy characterized by proliferation of monoclonal plasma cells remains incurable. Murine plasma cell tumors share common features with human MM. We used two cell lines (B3...

    Irma M. Sainz, Irma Isordia-Salas, Ricardo G. Espinola… in Cancer Immunology, Immunotherapy (2006)

  3. Article

    Open Access

    A monoclonal antibody against kininogen reduces inflammation in the HLA-B27 transgenic rat

    The human leukocyte antigen B27 (HLA-B27) transgenic rat is a model of human inflammatory bowel disease, rheumatoid arthritis and psoriasis. Studies of chronic inflammation in other rat models have demonstrate...

    James C Keith Jr, Irma M Sainz, Irma Isordia-Salas… in Arthritis Research & Therapy (2005)

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    A Monoclonal Antibody Recognizing an Iscosapeptide Sequence in the Heavy Chain of Human Factor XII Inhibits Surface-Catalyzed Activation

    A monoclonal antibody (mAb B7C9) to human factor XII was produced which blocked the surface mediated coagulant activity of factor XII but not the amidolysis of H-D-ProPheArg-pNA. The mAb epitope was localized ...

    Robin A. Pixley, Robert W. Colman in Kinins V (1989)