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Article
Molecular jackhammers eradicate cancer cells by vibronic-driven action
Through the actuation of vibronic modes in cell-membrane-associated aminocyanines, using near-infrared light, a distinct type of molecular mechanical action can be exploited to rapidly kill cells by necrosis. ...
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Article
Open AccessMutant p53 drives an immune cold tumor immune microenvironment in oral squamous cell carcinoma
The critical role of the tumor immune microenvironment (TIME) in determining response to immune checkpoint inhibitor (ICI) therapy underscores the importance of understanding cancer cell–intrinsic mechanisms d...
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Protocol
Monoclonal Antibodies Generation: Updates and Protocols on Hybridoma Technology
Since its inception in 1975, the hybridoma technology revolutionized science and medicine, facilitating discoveries in almost any field from the laboratory to the clinic. Many technological advancements have b...
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Article
Open AccessIntracellular targeting of annexin A2 inhibits tumor cell adhesion, migration, and in vivo grafting
Cytoskeletal-associated proteins play an active role in coordinating the adhesion and migration machinery in cancer progression. To identify functional protein networks and potential inhibitors, we screened an...
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Article
Targeting mammalian organelles with internalizing phage (iPhage) libraries
Techniques that are largely used for protein interaction studies and the discovery of intracellular receptors, such as affinity-capture complex purification and the yeast two-hybrid system, may produce inaccur...
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Article
Open AccessCombinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells
Phage display screening allows the study of functional protein–protein interactions at the cell surface, but investigating intracellular organelles remains a challenge. Here we introduce internalizing-phage li...
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Article
Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice
Gene expression can be regulated by chromatin modifiers, transcription factors and proteins that modulate DNA architecture. Among the latter, AT-hook transcription factors have emerged as multifaceted regulato...
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Chapter and Conference Paper
Efficient Group of Permutants for Proximity Searching
Modeling proximity searching problems in a metric space allows one to approach many problems in different areas, e.g. pattern recognition, multimedia search, or clustering. Recently there was proposed the perm...
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Article
Peptidase substrates via global peptide profiling
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Article
Design and construction of targeted AAVP vectors for mammalian cell transduction
Bacteriophage (phage) evolved as bacterial viruses, but can be adapted to transduce mammalian cells through ligand-directed targeting to a specific receptor. We have recently reported a new generation of hybri...
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Article
Molecular PET imaging of HSV1-tk reporter gene expression using [18F]FEAU
Non-invasive imaging of transgene expression requires the appropriate combination of a reporter gene and a reporter probe. [18F]FEAU positron emission tomography (PET) is used for the assessment of herpes simplex...
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Article
Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA
Proteins containing AT hooks bind A/T-rich DNA through a nine-amino-acid motif and are thought to co-regulate transcription by modifying the architecture of DNA, thereby enhancing the accessibility of promoter...
