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Article
Open AccessDengue virus-pandemic influenza virus co-infection results in enhanced influenza virus replication through inhibition of apoptosis
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Article
Open AccessSingle injection recombinant vesicular stomatitis virus vaccines protect ferrets against lethal Nipah virus disease
Nipah virus (NiV) is a highly pathogenic zoonotic agent in the family Paramyxoviridae that is maintained in nature by bats. Outbreaks have occurred in Malaysia, Singapore, India, and Bangladesh and have been asso...
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Article
Open AccessThe immunomodulating V and W proteins of Nipah virus determine disease course
The viral determinants that contribute to Nipah virus (NiV)-mediated disease are poorly understood compared with other paramyxoviruses. Here we use recombinant NiVs (rNiVs) to examine the contributions of the ...
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Article
Open AccessMost neutralizing human monoclonal antibodies target novel epitopes requiring both Lassa virus glycoprotein subunits
Lassa fever is a severe multisystem disease that often has haemorrhagic manifestations. The epitopes of the Lassa virus (LASV) surface glycoproteins recognized by naturally infected human hosts have not been i...
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Article
Open AccessPathogenic Differences between Nipah Virus Bangladesh and Malaysia Strains in Primates: Implications for Antibody Therapy
Nipah virus (NiV) is a paramyxovirus that causes severe disease in humans and animals. There are two distinct strains of NiV, Malaysia (NiVM) and Bangladesh (NiVB). Differences in transmission patterns and mortal...
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Protocol
Production of Antigens for ELISA
Immunologic assays such as ELISA allow detection of either virus antigens or the host’s immune response to antigens associated with prior infections and offer a powerful means to approach understanding the epi...
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Protocol
ELISA Methods for the Detection of Ebolavirus Infection
Ebola viruses are high-priority pathogens first discovered in rural Africa associated with sporadic outbreaks of severe hemorrhagic disease in humans and nonhuman primates. Little is known about the disease ec...
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Article
Open AccessInfection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants
Zaire Ebolavirus (ZEBOV) continues to pose a significant threat to human health as highlighted by the recent epidemic that originated in West Africa and the ongoing outbreak in the Democratic Rep...
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Article
Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever
Thomas Geisbert and colleagues show that a cocktail of monoclonal antibodies protects cynomolgus monkeys from lethal Lassa fever virus infection, including when administration is delayed by more than a week af...
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Article
Open AccessField validation of recombinant antigen immunoassays for diagnosis of Lassa fever
Lassa fever, a hemorrhagic fever caused by Lassa virus (LASV), is endemic in West Africa. It is difficult to distinguish febrile illnesses that are common in West Africa from Lassa fever based solely on a pati...
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Article
Erratum: Post-exposure treatments for Ebola and Marburg virus infections
Nature Reviews Drug Discovery (2018); 10.1038/nrd.2017.251 The discussion of the phase II trial of TKM-130803 reported in reference 156 has been revised to correct inaccuracies in the original text.
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Article
Post-exposure treatments for Ebola and Marburg virus infections
The filoviruses, Ebola virus and Marburg virus, cause lethal haemorrhagic fever in humans and non-human primates (NHPs), and there are currently no licensed va...
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Open AccessAuthor Correction: Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessVesicular Stomatitis Virus-Based Vaccine Protects Mice against Crimean-Congo Hemorrhagic Fever
Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne bunyavirus, can cause a life-threatening hemorrhagic syndrome in humans but not in its animal host. The virus is widely distributed throughout southe...
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Article
Open AccessAntagonism of STAT1 by Nipah virus P gene products modulates disease course but not lethal outcome in the ferret model
Nipah virus (NiV) is a pathogenic paramyxovirus and zoononis with very high human fatality rates. Previous protein over-expression studies have shown that various mutations to the common N-terminal STAT1-bindi...
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Article
Open AccessRational design of universal immunotherapy for TfR1-tropic arenaviruses
Certain arenaviruses that circulate in rodent populations can cause life-threatening hemorrhagic fevers when they infect humans. Due to their efficient transmission, arenaviruses pose a severe risk for outbrea...
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Article
Open AccessImmune correlates of postexposure vaccine protection against Marburg virus
Postexposure immunization can prevent disease and reduce transmission following pathogen exposure. The rapid immunostimulatory properties of recombinant vesicular stomatitis virus (rVSV)-based vaccines make th...
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Article
Open AccessPrior vaccination with rVSV-ZEBOV does not interfere with but improves efficacy of postexposure antibody treatment
A replication-competent vesicular stomatitis virus vaccine expressing the Ebola virus (EBOV) glycoprotein (GP) (rVSV-ZEBOV) was successfully used during the 2013-16 EBOV epidemic. Additionally, chimeric and hu...
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Article
Open AccessIntranasal exposure of African green monkeys to SARS-CoV-2 results in acute phase pneumonia with shedding and lung injury still present in the early convalescence phase
We recently reported the development of the first African green monkey (AGM) model for COVID-19 based on a combined liquid intranasal (i.n.) and intratracheal (i.t.) exposure to severe acute respiratory syndro...
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Article
Open AccessAntibodies from Sierra Leonean and Nigerian Lassa fever survivors cross-react with recombinant proteins representing Lassa viruses of divergent lineages
Lassa virus (LASV) is the causative agent of Lassa fever, an often-fatal hemorrhagic disease that is endemic in West Africa. Seven genetically distinct LASV lineages have been identified. As part of CEPI’s (Co...
