-
Article
Open AccessNatural history of nonhuman primates after conjunctival exposure to Ebola virus
Transmission of Ebola virus (EBOV) primarily occurs via contact exposure of mucosal surfaces with infected body fluids. Historically, nonhuman primate (NHP) challenge studies have employed intramuscular (i.m.)...
-
Article
Open AccessSingle dose rVSVΔG-JUNVGP vaccine protects guinea pigs against lethal Junin virus challenge
Junin virus (JUNV) is a pathogen of biodefense importance due to its potential for aerosol transmission and mortality rates reaching 30%. Currently, there are no JUNV vaccines licensed by the United States Foo...
-
Article
Broadly neutralizing antibody cocktails targeting Nipah virus and Hendra virus fusion glycoproteins
Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses (HNVs) causing respiratory illness and severe encephalitis in humans, with fatality rates of 50–100%. There are no licensed therapeutics or vaccines t...
-
Article
Open AccessCombination therapy protects macaques against advanced Marburg virus disease
Monoclonal antibodies (mAbs) and remdesivir, a small-molecule antiviral, are promising monotherapies for many viruses, including members of the genera Marburgvirus and Ebolavirus (family Filoviridae), and more re...
-
Article
Open AccessA single dose investigational subunit vaccine for human use against Nipah virus and Hendra virus
Nipah and Hendra viruses are highly pathogenic bat-borne paramyxoviruses recently included in the WHO Blueprint priority diseases list. A fully registered horse anti-Hendra virus subunit vaccine has been in us...
-
Article
Establishment of an African green monkey model for COVID-19 and protection against re-infection
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for an unprecedented global pandemic of COVID-19. Animal models are urgently needed to study the pathogenesis of COVID-19 and to scre...
-
Article
Open AccessAntibodies from Sierra Leonean and Nigerian Lassa fever survivors cross-react with recombinant proteins representing Lassa viruses of divergent lineages
Lassa virus (LASV) is the causative agent of Lassa fever, an often-fatal hemorrhagic disease that is endemic in West Africa. Seven genetically distinct LASV lineages have been identified. As part of CEPI’s (Co...
-
Article
Open AccessIntranasal exposure of African green monkeys to SARS-CoV-2 results in acute phase pneumonia with shedding and lung injury still present in the early convalescence phase
We recently reported the development of the first African green monkey (AGM) model for COVID-19 based on a combined liquid intranasal (i.n.) and intratracheal (i.t.) exposure to severe acute respiratory syndro...
-
Article
Open AccessPrior vaccination with rVSV-ZEBOV does not interfere with but improves efficacy of postexposure antibody treatment
A replication-competent vesicular stomatitis virus vaccine expressing the Ebola virus (EBOV) glycoprotein (GP) (rVSV-ZEBOV) was successfully used during the 2013-16 EBOV epidemic. Additionally, chimeric and hu...
-
Article
Open AccessImmune correlates of postexposure vaccine protection against Marburg virus
Postexposure immunization can prevent disease and reduce transmission following pathogen exposure. The rapid immunostimulatory properties of recombinant vesicular stomatitis virus (rVSV)-based vaccines make th...
-
Article
Open AccessRational design of universal immunotherapy for TfR1-tropic arenaviruses
Certain arenaviruses that circulate in rodent populations can cause life-threatening hemorrhagic fevers when they infect humans. Due to their efficient transmission, arenaviruses pose a severe risk for outbrea...
-
Article
Open AccessAntagonism of STAT1 by Nipah virus P gene products modulates disease course but not lethal outcome in the ferret model
Nipah virus (NiV) is a pathogenic paramyxovirus and zoononis with very high human fatality rates. Previous protein over-expression studies have shown that various mutations to the common N-terminal STAT1-bindi...
-
Article
Open AccessVesicular Stomatitis Virus-Based Vaccine Protects Mice against Crimean-Congo Hemorrhagic Fever
Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne bunyavirus, can cause a life-threatening hemorrhagic syndrome in humans but not in its animal host. The virus is widely distributed throughout southe...
-
Article
Open AccessAuthor Correction: Infection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
-
Article
Post-exposure treatments for Ebola and Marburg virus infections
The filoviruses, Ebola virus and Marburg virus, cause lethal haemorrhagic fever in humans and non-human primates (NHPs), and there are currently no licensed va...
-
Article
Erratum: Post-exposure treatments for Ebola and Marburg virus infections
Nature Reviews Drug Discovery (2018); 10.1038/nrd.2017.251 The discussion of the phase II trial of TKM-130803 reported in reference 156 has been revised to correct inaccuracies in the original text.
-
Article
Open AccessField validation of recombinant antigen immunoassays for diagnosis of Lassa fever
Lassa fever, a hemorrhagic fever caused by Lassa virus (LASV), is endemic in West Africa. It is difficult to distinguish febrile illnesses that are common in West Africa from Lassa fever based solely on a pati...
-
Article
Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever
Thomas Geisbert and colleagues show that a cocktail of monoclonal antibodies protects cynomolgus monkeys from lethal Lassa fever virus infection, including when administration is delayed by more than a week af...
-
Article
Open AccessInfection with the Makona variant results in a delayed and distinct host immune response compared to previous Ebola virus variants
Zaire Ebolavirus (ZEBOV) continues to pose a significant threat to human health as highlighted by the recent epidemic that originated in West Africa and the ongoing outbreak in the Democratic Rep...
-
Protocol
Production of Antigens for ELISA
Immunologic assays such as ELISA allow detection of either virus antigens or the host’s immune response to antigens associated with prior infections and offer a powerful means to approach understanding the epi...
