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Article
Open AccessTauP301L disengages from the proteosome core complex and neurogranin coincident with enhanced neuronal network excitability
Tauopathies are characterised by the pathological accumulation of misfolded tau. The emerging view is that toxic tau species drive synaptic dysfunction and potentially tau propagation before measurable neurode...
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Article
The Perceived Causes of Problems with Substance Use, Gambling, and Other Behavioural Addictions from the Perspective of People with Lived Experience: a Mixed-Methods Investigation
This mixed-methods study examined the perceived causes of problematic substance use, gambling, and other behaviours from the perspective of individuals with lived experience, using the syndrome model of addict...
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Article
Open AccessEpigallocatechin Gallate Modulates Microglia Phenotype to Suppress Pro-inflammatory Signalling Cues and Inhibit Phagocytosis
Microglia are crucial players in the pathogenesis of late-onset Alzheimer’s disease (AD), with evidence for both deleterious and beneficial effects. Identifying interventions to modulate microglial responsiven...
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Article
Migrating from Land-Based to Online Gambling: Sex, Mental Health and Motivational Predictors
Online gambling is associated with higher levels of problem gambling and an array of adverse mental health characteristics. No longitudinal study has identified factors that lead people who gamble in land-base...
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Article
Are There Riskier Types of Gambling?
Gambling-related harm is a public health issue requiring market regulation and efforts aimed at prevention and treatment. An important consideration for the regulation of gambling is whether certain types of g...
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Article
Cognitive Factors that Predict Gambling Fallacy Endorsement
Gambling fallacies are a collection of error-stricken beliefs about gambling and how gambling works. Gambling fallacies, while common in the general public, appear to increase as a function of gambling severit...
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Article
Harm Minimization Training, Knowledge, and Behaviour of Canadian Casino Employees
Casino employees regularly interact with problem and at-risk gamblers and thus have considerable potential to both prevent and reduce gambling-related harm. While harm minimization (HM) and responsible gamblin...
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Article
Responsible Gambling in Canada: An Analysis of the RG Check Patron Surveys
This study analyzed the Responsible Gambling Check patron survey data from Canadian casinos and racinos collected from 2011-2019 (18,580 patrons and 75 venues). The results indicated increasing awareness and u...
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Article
Gambling in Canada During the COVID Lockdown: Prospective National Survey
The current study investigated the impact of the COVID pandemic lockdown on gambling and problem gambling in Canada. The AGRI National Project’s online panel participants (N = 3449) provided baseline gambling dat...
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Article
Indigenous Gambling and Problem Gambling in Canada
The present study provides a profile of Canadian Indigenous gambling and problem gambling using the 2018 Canadian Community Health Survey (CCHS) (n = 23,952 adults; 1,324 Indigenous) and an online panel survey of...
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Article
Predictors of gambling and problem gambling in Canada
The purpose of this study is to provide an updated profile of gamblers and problem gamblers in Canada and to identify characteristics most strongly associated with problem gambling.
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Article
Open AccessPredicting future harm from gambling over a five-year period in a general population sample: a survival analysis
There is little longitudinal evidence on the cumulative risk of harm from gambling associated with excess spending and frequency of play. The present study sought to assess the risk of gambling problems over a...
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Article
Open AccessA series of helical α-synuclein fibril polymorphs are populated in the presence of lipid vesicles
α-Synuclein (αS) deposition is a defining characteristic of Parkinson’s disease (PD) pathology, and other synucleinopathies. αS aggregates in disease, leading to the generation of neuronal inclusions known as ...
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Article
Implicit Memory Associations and Gambling
Associations that people report in response to words or phrases (‘implicit associations’) may provide information about their interest and engagement in certain activities that might not have been reported if ...
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Article
The Multidimensional Structure of Problem Gambling: An Evaluation of Four Gambling Categorization Instruments from an International Online Survey of Gamblers
To examine the underlying dimensionality and structure of problem gambling using a comprehensive range of problem gambling assessments from an international online survey of gamblers. A total of 12,521 gambler...
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Protocol
Analysis of Protein Glycation Using Phenylboronate Acrylamide Gel Electrophoresis
Carbohydrate modification of proteins adds complexity and diversity to the proteome. However, undesired carbohydrate modifications also occur in the form of glycation, which have been implicated in diseases su...
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Article
Open AccessThe importance of friends and family to recreational gambling, at-risk gambling, and problem gambling
The variables correlated with problem gambling are routinely assessed and fairly well established. However, problem gamblers were all ‘at-risk’ and ‘recreational’ gamblers at some point. Thus, it is instructiv...
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Article
Zika virus induces astrocyte differentiation in neural stem cells
Zika virus (ZIKV) is a rapidly emerging flavivirus that has been associated with a number of congenital neurological manifestations. Here, we show that ZIKV replicated efficiently in mouse neural stem cells (m...
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Chapter
Environmental Lead and Wild Birds: A Review
Lead is a persistent inorganic environmental pollutant that affects humans and animals worldwide. Avian species are especially susceptible to lead exposure through consumption of lead ammunition, lead fishing ...
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Article
Open AccessThe protective role of religiosity against problem gambling: findings from a five-year prospective study
Little research has examined the potential protective influence of religiosity against problem gambling; a common addictive behavior, and one with a host of associated negative health and social outcomes. The ...
