6 Result(s)
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Article
Open AccessDNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon
Genetic variants in the DNA methyltransferase 3 A (DNMT3A) locus have been associated with inflammatory bowel disease (IBD). DNMT3A is part of the epigenetic machinery physiologically involved in DNA methylati...
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Article
Open AccessLow-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice
Mutations in mitochondrial DNA (mtDNA) lead to heteroplasmy, i.e., the intracellular coexistence of wild-type and mutant mtDNA strands, which impact a wide spectrum of diseases but also physiological processes...
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Article
Open AccessPublisher Correction: Identification and characterization of two functional variants in the human longevity gene FOXO3
The original version of this Article contained an error in the spelling of the author Robert Häsler, which was incorrectly given as Robert Häesler. This has now been corrected in both the PDF and HTML versions...
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Article
Open AccessIdentification and characterization of two functional variants in the human longevity gene FOXO3
FOXO3 is consistently annotated as a human longevity gene. However, functional variants and underlying mechanisms for the association remain unknown. Here, we perform resequencing of the FOXO3 locus and single-nu...
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Open AccessAnalysis of intestinal microbiota in hybrid house mice reveals evolutionary divergence in a vertebrate hologenome
Recent evidence suggests that natural selection operating on hosts to maintain their microbiome contributes to the emergence of new species, that is, the ‘hologenomic basis of speciation’. Here we analyse the ...
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Article
Transcriptome and genome sequencing uncovers functional variation in humans
Genome sequencing projects are discovering millions of genetic variants in humans, and interpretation of their functional effects is essential for understanding the genetic basis of variation in human traits. ...
