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Article
Open AccessA phase 1 study to assess the absolute bioavailability, mass balance, pharmacokinetics, metabolism, and excretion of [14C]-mobocertinib, an oral inhibitor of EGFR exon 20 insertion mutations, in healthy participants
Mobocertinib (TAK-788) is a first-in-class oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that received accelerated approval for the treatment of patients with non-small cell lung cance...
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Article
Open AccessTeam IHMC at the 2020 Cybathlon: a user-centered approach towards personal mobility exoskeletons
The past few decades have seen rapid advancements in exoskeleton technology, with a considerable shift towards applications involving users with gait pathologies. Commercial devices from ReWalk, Ekso Bionics, ...
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Chapter and Conference Paper
Obstacle Awareness Subsystem for Higher Exoskeleton Safety
Exoskeletons are electromechanical systems whose main purpose is to facilitate the workload or to enable the mobility of their users. They combine human intelligence and machine power to strengthen both - thus...
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Article
Private Benefits of Conservation and Procurement Auction Performance
Payment-for-ecosystem services programs may use auctions to procure ecosystem services for cost-effective conservation. Conservation practices that generate private benefits (e.g., on-site benefits of erosion ...
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Article
Shifting habitats expose fishing communities to risk under climate change
Climate change is expected to have a profound impact on the distribution, abundance and diversity of marine species globally1,2. These ecological impacts of climate change will affect human communities dependent ...
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Article
Open AccessEpitope determines efficacy of therapeutic anti-Tau antibodies in a functional assay with human Alzheimer Tau
In Alzheimer’s disease (AD) and other tauopathies, the cytosolic protein Tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration. Clinical progression is ...
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Article
Open AccessEngineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions
Autoantibody-mediated diseases are currently treated with intravenous immunoglobulin, which is thought to act in part via blockade of Fc gamma receptors, thereby inhibiting autoantibody effector functions and ...
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Article
A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment
Hyer et al. generate a potent and specific small-molecule inhibitor of the E1 ubiquitin-activating enzyme UBE1 that has antitumor activity in mice against a wide variety of tumor types.
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Chapter
Team VALOR’s ESCHER: A Novel Electromechanical Biped for the DARPA Robotics Challenge
The Electric Series Compliant Humanoid for Emergency Response (ESCHER) platform represents the culmination of four years of development at Virginia Tech to produce a full sized force controlled humanoid robot ...
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Article
Open AccessDiscovery of a junctional epitope antibody that stabilizes IL-6 and gp80 protein:protein interaction and modulates its downstream signaling
Protein:protein interactions are fundamental in living organism homeostasis. Here we introduce VHH6, a junctional epitope antibody capable of specifically recognizing a neo-epitope when two proteins interact, ...
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Chapter
Therapeutic Implications of Angiogenesis in Cancer
Angiogenesis is one of the hallmarks of cancer. Many primed cells endowed with all cancer characteristics arise in our body but they cannot progress to become cancer-disease without activating angiogenesis. Th...
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Chapter
The Future of Regulatory Plant Science
Regulatory plant science has a unique evolution which distinguishes it from many disciplines with similar functions. The design and role of most National Plant Protection Organizations is closely linked to the...
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Chapter and Conference Paper
Mid-infrared Laser Based Gas Sensor Technologies for Environmental Monitoring, Medical Diagnostics, Industrial and Security Applications
Recent advances in the development of compact sensors based on mid-infrared continuous wave (CW), thermoelectrically cooled (TEC) and room temperature operated quantum cascade lasers (QCLs) for the detection, ...
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Chapter
The Biosecurity Continuum and Trade: Pre-border Operations
Pre-border aspects of the biosecurity continuum associated with trade are internal arrangements of the NPPO that address import and export needs of the country. In most countries, these programmes are evolving...
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Chapter
The Role of Pest Risk Analysis in Plant Biosecurity
The practice of risk analysis in plant quarantine is known as Pest Risk Analysis. The process is closely linked to the international regulatory framework formed by the World Trade Organization Agreement on the...
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Chapter
The International Regulatory Framework
The International Plant Protection Convention (IPPC) is an international treaty that came into existence during 1952, superseding all previous international plant protection agreements. The IPPC is intended to...
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Article
Continuously Tunable 250 GHz Gyrotron with a Double Disk Window for DNP-NMR Spectroscopy
In this paper, we describe the design and experimental results from the rebuild of a 250 GHz gyrotron used for Dynamic Nuclear Polarization enhanced Nuclear Magnetic Resonance spectroscopy on a 380 MHz spectro...
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Chapter and Conference Paper
Defending against the Unknown Enemy: Applying FlipIt to System Security
Most cryptographic systems carry the basic assumption that entities are able to preserve the secrecy of their keys. With attacks today showing ever increasing sophistication, however, this tenet is eroding. “A...
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Article
Dipolar recoupling in MAS spectra of biological solids
In combination with magic angle spinning, dipolar recoupling yields solid state NMR spectral assignments and provides constraints on internuclear distances and torsion angles. The method offers a fresh approac...
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Article
Analyzing the turnout-competition link with aggregate cross-sectional data
Numerous papers by Public Choice oriented scholars and others have sought to test the hypothesis inspired by Downs (1957) that, ceteris paribus, turnout should be higher when elections are close. Most look in ...
