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Article
Associations of dietary, lifestyle, other participant characteristics, and oxidative balance scores with plasma F2-isoprostanes concentrations in a pooled cross-sectional study
Plasma F2-isoprostanes (FiP) concentration, a reliably measured, valid, systemic oxidative stress biomarker, has been associated with multiple health-related outcomes; however, associations of most individual die...
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Article
Associations of dietary and lifestyle oxidative balance scores with mortality risk among older women: the Iowa Women’s Health Study
Substantial basic science evidence suggests that oxidative stress may play a role in aging-related health outcomes, including cardiovascular diseases (CVD) and cancer, and oxidative stress markers were linked ...
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Article
A novel evolutionary-concordance lifestyle score is inversely associated with all-cause, all-cancer, and all-cardiovascular disease mortality risk
Evolutionary discordance may contribute to the high burden of chronic disease-related mortality in modern industrialized nations. We aimed to investigate the associations of a 7-component, equal-weight, evolut...
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Article
Genetic polymorphisms in the cyclooxygenase-1 and cyclooxygenase-2 genes and risk of colorectal adenoma
Cyclooxygenase (COX) enzymes, COX1 and COX2, are key in converting arachidonic acid (AA) into prostaglandins that have been associated with colorectal carcinogenesis. The aim of our study was to investigate as...
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Chapter
Calcium and Vitamin D
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Article
A summary measure of pro- and anti-oxidant exposures and risk of incident, sporadic, colorectal adenomas
Despite compelling basic science evidence, the search for causal associations linking specific pro- and anti-oxidants to presumably oxidative stress-related neoplasms, such as colorectal adenoma, has produced ...
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Article
Folate Intake, MTHFR C677T Polymorphism, Alcohol Consumption, and Risk for Sporadic Colorectal Adenoma (United States)
Objective: The purpose of this study was to investigate whether folate intake is associated with risk for incident sporadic colorectal adenoma, and whether the association differs according to methylenetetrahydr...
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Chapter
Diet and Nutrition in the Etiology and Primary Prevention of Colon Cancer
Cancer of the colon and rectum is the second most common cause of cancer mortality in Westernized countries (1,2). Incidence rates vary approx 20-fold around the world (1, 2). The international differences, migra...
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Article
Diet and risk of colon cancer in a large prospective study of older women: an analysis stratified on family history (Iowa, United States)
Objective: The purpose was to investigate whether dietary associations with risk of colon cancer in women differ by family history of the disease.
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Chapter
Diet and Nutrition in the Etiology and Primary Prevention of Colon Cancer
In the United States, cancer is the second leading cause of death, and cancer of the colon and rectum is the second most common cause of cancer mortality (1). It is estimated that most cancers may be preventab...
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Article
Dietary cholesterol, fat, and lung cancer incidence among older women: The Iowa Women's Health Study (United States)
To test the hypothesis that a high intake of dietary cholesterol and fat is associated with elevated risks of lung cancer, we analyzed data from a population-based, prospective, cohort study conducted among 41...
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Article
Difficulty becoming pregnant and family history as interactive risk factors for postmenopausal breast cancer: the Iowa Women's Health Study
We recently provided data from a prospective cohort study of postmenopausal women which suggested that a first livebirth at age 30 or older (cf before age 20) was associated with a twofold increased risk of breas...
