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Effects of tumor-infiltrating CD8+ T cells, PD1/PD-L1 axis, and expression patterns of HLA class I on the prognosis of patients with malignant pleural mesothelioma who underwent extra-pleural pneumonectomy

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  1. Article

    Open Access

    Characterizing soluble immune checkpoint molecules and TGF-β1,2,3 in pleural effusion of malignant pleural mesothelioma

    The clinical impact of soluble molecules in pleural effusion (PE) is unclear in patients with malignant pleural mesothelioma (MPM). In this single-center, retrospective, observational study, we assessed solubl...

    Riki Okita, Tomoya Senoo, Yuka Mimura-Kimura, Yusuke Mimura in Scientific Reports (2024)

  2. Article

    Open Access

    Preoperative neutrophil-to-lymphocyte ratio correlates with PD-L1 expression in immune cells of patients with malignant pleural mesothelioma and predicts prognosis

    We assessed the prognostic value of five complex inflammatory and nutritional parameters, namely neutrophil-to-lymphocyte ratio (NLR), prognostic nutritional index (PNI), C-reactive protein-to-NLR ratio (C/NLR...

    Riki Okita, Nobutaka Kawamoto, Masanori Okada, Hidetoshi Inokawa in Scientific Reports (2023)

  3. Article

    Open Access

    Pneumatosis intestinalis after gefitinib therapy for pulmonary adenocarcinoma: a case report

    Pneumatosis intestinalis (PI) is defined as the presence of gas in the bowel wall and is a relatively rare finding. PI has been associated with various pathological conditions and medications. Although several...

    Ai Maeda, Masao Nakata, Katsuhiko Shimizu in World Journal of Surgical Oncology (2016)

  4. Article

    Open Access

    Clinical significance of dual-time-point 18F-FDG PET imaging in resectable non-small cell lung cancer

    The maximal standardized uptake value (SUVmax) of pulmonary lesions on dual-time-point (DTP) fluorodeoxyglucose positron emission tomography (FDG-PET) has been shown to be useful for differentiation between ma...

    Katsuhiko Shimizu, Riki Okita, Shinsuke Saisho, Takuro Yukawa in Annals of Nuclear Medicine (2015)

  5. Article

    Open Access

    Preoperative neutrophil/lymphocyte ratio and prognostic nutritional index predict survival in patients with non-small cell lung cancer

    The immunological status, consisting of “inflammation status” and “nutritional condition,” is important for the survival of patients with various cancers, including non-small cell lung cancer (NSCLC). The neut...

    Katsuhiko Shimizu, Riki Okita, Shinsuke Saisho in World Journal of Surgical Oncology (2015)

  6. Article

    Open Access

    Cyclooxygenase-2 expression is a prognostic biomarker for non-small cell lung cancer patients treated with adjuvant platinum-based chemotherapy

    Adjuvant chemotherapy after the resection of stage IB-IIIA non-small cell lung cancer (NSCLC) is now the standard of care based on large-scale phase III trials and a meta-analysis. However, chemotherapy has pl...

    Katsuhiko Shimizu, Takuro Yukawa, Riki Okita in World Journal of Surgical Oncology (2015)

  7. Article

    Open Access

    Difference in prognostic values of maximal standardized uptake value on fluorodeoxyglucose-positron emission tomography and cyclooxygenase-2 expression between lung adenocarcinoma and squamous cell carcinoma

    The maximal standardized uptake value (SUVmax) on fluorodeoxyglucose-positron emission tomography (FDG-PET) for primary tumors is correlated with clinicopathological and prognostic factors in patients with non...

    Katsuhiko Shimizu, Ai Maeda, Takuro Yukawa in World Journal of Surgical Oncology (2014)

  8. Article

    Open Access

    A case report of intrapulmonary schwannoma

    A 38-year-old man without any symptoms was admitted to our institution because of an abnormal shadow found incidentally on a chest X-ray. Chest computed tomography showed a round mass in the lingular segment o...

    Takuro Yukawa, Katsuhiko Shimizu in General Thoracic and Cardiovascular Surgery (2014)