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Article
Open AccessDerivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice
Central nervous system (CNS) lesions become surrounded by neuroprotective borders of newly proliferated reactive astrocytes; however, fundamental features of these cells are poorly understood. Here we show tha...
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Article
Open AccessErythropoietin restrains the inhibitory potential of interneurons in the mouse hippocampus
Severe psychiatric illnesses, for instance schizophrenia, and affective diseases or autism spectrum disorders, have been associated with cognitive impairment and perturbed excitatory-inhibitory balance in the ...
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Article
Norepinephrine modulates calcium dynamics in cortical oligodendrocyte precursor cells promoting proliferation during arousal in mice
Oligodendrocytes, the myelinating cells of the central nervous system (CNS), are generated from oligodendrocyte precursor cells (OPCs) that express neurotransmitter receptors. However, the mechanisms that affe...
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Article
Astrocyte layers in the mammalian cerebral cortex revealed by a single-cell in situ transcriptomic map
Although the cerebral cortex is organized into six excitatory neuronal layers, it is unclear whether glial cells show distinct layering. In the present study, we developed a high-content pipeline, the large-ar...
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Article
GDF10 is a signal for axonal sprouting and functional recovery after stroke
Stroke is the leading cause of adult disability. This study shows that the secreted factor GDF10 is a signal for the formation of new brain connections that lead to recovery after stroke and can be manipulated...