-
Article
Open AccessUse of [11C]choline PET/CT for visualization of four hyperactive parathyroid glands in a patient with renal hyperparathyroidism
-
Article
Open AccessAn urgent call to raise the bar in oncology
Important breakthroughs in medical treatments have improved outcomes for patients suffering from several types of cancer. However, many oncological treatments approved by regulatory agencies are of low value a...
-
Article
Open AccessRelationship between serum B12 concentrations and mortality: experience in NHANES
There is conflicting evidence in the literature on the association between (elevated) serum B12 concentrations and subsequent disease or mortality. We evaluated in the NHANES general population the association...
-
Article
Open AccessBeta-Blocker Use in Pregnancy and Risk of Specific Congenital Anomalies: A European Case-Malformed Control Study
The prevalence of chronic hypertension is increasing in pregnant women. Beta-blockers are among the most prevalent anti-hypertensive agents used in early pregnancy.
-
Article
Open AccessWhat supervisors say in their feedback: construction of CanMEDS roles in workplace settings
The CanMEDS framework has been widely adopted in residency education and feedback processes are guided by it. It is, however, only one of many influences on what is actually discussed in feedback. The sociohis...
-
Reference Work Entry In depth
Diseases of Renal Microcirculation: Diabetic Nephropathy
The prevalence of diabetes mellitus and its long-term vascular complications are increasing worldwide. Diabetic nephropathy is one of the main microvascular complications of diabetes and is characterized by th...
-
Article
Open AccessCirculating peroxiredoxin 4 and type 2 diabetes risk: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study
Oxidative stress plays a key role in the development of type 2 diabetes mellitus. We previously showed that the circulating antioxidant peroxiredoxin 4 (Prx4) is associated with cardiometabolic risk factors. W...
-
Article
PS4 - 22. HDL-cholesterol, Apolipoprotein A-I/A-II, and HDL-cholesterol particle composition for the risk of develo** type 2 diabetes in the community: the PREVEND Study
High density lipoproteins (HDL) have been recently proposed to stimulate beta-cell function in vitro. The extent to which incident type 2 diabetes (T2DM) relates to plasma levels of HDL-cholesterol and HDL-associ...
-
Article
PS4 - 23. Bilirubin and risk of type 2 diabetes: a mendelian randomization approach
A higher circulating bilirubin, as an antioxidant, has been shown to be associated with a lower risk of cardiometabolic traits/diseases. We aimed to prospectively investigate the association of serum bilirubin...
-
Article
Increased insulin requirements during exercise at very high altitude in type 1 diabetes
Steeds meer mensen met type 1 diabetes mellitus doen aan extreme sporten, waaronder het maken van bergtochten op zeer grote hoogte (3.500-5.500m). Veel factoren op hoogte, zoals kou, hoogteziekte, een verminde...
-
Article
External validation of the KORA S4/F4 prediction models for the risk of develo** type 2 diabetes in older adults: the PREVEND study
Recently, prediction models for type 2 diabetes mellitus (T2DM) in older adults (aged ≥55 year) were developed in the KORA S4/F4 study, Augsburg, Germany. We aimed to externally validate the KORA models in a D...
-
Article
PS9 - 48. External validation of the KORA S4/F4 prediction models for the risk of develo** type 2 diabetes in older adults: the PREVEND Study
Recently, prediction models for type 2 diabetes mellitus (T2DM) in older adults (aged =55y) were developed in the KORA S4/F4 study, Augsburg, Germany. We aimed to externally validate the KORA models in a Dutch...
-
Article
Open AccessIs social stress in the first half of life detrimental to later physical and mental health in both men and women?
This study examined gender differences in the associations between affection- and status-related stressors encountered in the first half of life and physical and mental health problems later on. Based on the t...
-
Article
Limited effect of patient and disease characteristics on compliance with hospital antimicrobial guidelines
Physicians frequently deviate from guidelines that promote prudent use of antimicrobials. We explored to what extent patient and disease characteristics were associated with compliance with guideline recommend...
-
Chapter
Insulin and Blood Pressure
Insulin resistance and compensatory hyperinsulinaemia are common features of obesity and non-insulin-dependent diabetes mellitus, conditions that are frequently complicated by hypertension [1,2]. The documenta...
-
Chapter
Insulin and Blood Pressure
Insulin resistance and compensatory hyperinsulinaemia are common features of obesity and non-insulin-dependent diabetes mellitus, conditions that are frequently complicated by hypertension [1,2]. The documenta...
