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Article
Pretreatment parameters associated with hemorrhagic transformation among successfully recanalized medium vessel occlusions
Although pretreatment radiographic biomarkers are well established for hemorrhagic transformation (HT) following successful mechanical thrombectomy (MT) in large vessel occlusion (LVO) strokes, they are yet to...
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Article
Insomnia and Its Non-Pharmacological Management in Older Adults
Insomnia, a sleep disorder involving difficulty falling, maintaining, or obtaining good quality sleep, is a common health complaint in older adults. The purpose of this review is to summarize the prevalence, r...
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Article
Open AccessEncapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Clinical studies on the treatment of type 1 diabetes with device-encapsulated pancreatic precursor cells derived from human embryonic stem cells found that insulin output was insufficient for clinical benefit....
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Article
Open AccessPhotoswitchable gating of non-equilibrium enzymatic feedback in chemically communicating polymersome nanoreactors
The circadian rhythm generates out-of-equilibrium metabolite oscillations that are controlled by feedback loops under light/dark cycles. Here we describe a non-equilibrium nanosystem comprising a binary popula...
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Article
Open AccessNanocages engineered from Bacillus Calmette-Guerin facilitate protective Vγ2Vδ2 T cell immunity against Mycobacterium tuberculosis infection
Tuberculosis (TB), induced by Mycobacterium tuberculosis (Mtb) infection, remains a top killer among infectious diseases. While Bacillus Calmette-Guerin (BCG) is the sole TB vaccine, the clumped-clustered feature...
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Article
Open AccessSelective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool
Targeted protein degradation tools are becoming a new therapeutic modality, allowing small molecule ligands to be reformulated as heterobifunctional molecules (PROteolysis Targeting Chimeras, PROTACs) that rec...
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Article
Effects of COVID-19 pandemic on pediatric kidney transplant in the United States
In March 2020, COVID-19 infections began to rise exponentially in the USA, placing substantial burden on the healthcare system. As a result, there was a rapid change in transplant practices and policies, with ...
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Article
Open AccessAuthor Correction: Bis-biguanide dihydrochloride inhibits intracellular replication of M. tuberculosis and controls infection in mice
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessValproate-induced hyperammonemic encephalopathy: a case report
Hyperammonemic encephalopathy is a rare and serious adverse reaction to valproate. Although there is documentation of this reaction in previous reports, very little is still known about the exact mechanism of ...
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Reference Work Entry In depth
Elastin in Vascular Grafts
The clinical demand for a superior vascular graft is rising due to the increase in cardiovascular disease with an aging population. Despite decades of research, clinically translatable solutions remain limited...
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Living Reference Work Entry In depth
Elastin in Vascular Grafts
The clinical demand for a superior vascular graft is rising due to the increase in cardiovascular disease with an aging population. Despite decades of research, clinically translatable solutions remain limited...
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Article
Polyethylenimine-coated iron oxide magnetic nanoparticles for high efficient gene delivery
Properties of magnetic nanoparticles (MNPs) are of notable interest in many fields of biomedical engineering, especially for gene therapy. In this paper, we report a method for synthesis and delivery of MNPs l...
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Article
CRIM1 is necessary for coronary vascular endothelial cell development and homeostasis
Endothelial cells form a critical component of the coronary vasculature, yet the factors regulating their development remain poorly defined. Here we reveal a novel role for the transmembrane protein CRIM1 in m...
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Article
Open AccessIntegrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies
Identification of single nucleotide polymorphisms (SNPs) associated with gene expression levels, known as expression quantitative trait loci (eQTLs), may improve understanding of the functional role of phenoty...
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Chapter and Conference Paper
Measuring Stakeholders’ Perceptions of Cybersecurity for Renewable Energy Systems
Renewable energy systems need to be able to make frequent and rapid adjustments to address shifting solar and wind production. This requires increasingly sophisticated industrial control systems (ICS). But, th...
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Article
Open AccessIn vivo human adipose-derived mesenchymal stem cell tracking after intra-articular delivery in a rat osteoarthritis model
Human adipose-derived mesenchymal stem cells (haMSCs) have shown efficacy in treating osteoarthritis (OA) both preclinically and clinically via intra-articular (IA) injection. However, understanding the mode o...
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Article
Open AccessBis-biguanide dihydrochloride inhibits intracellular replication of M. tuberculosis and controls infection in mice
While there is an urgent need to develop new and effective drugs for treatment of tuberculosis (TB) and multi-drug resistant TB (MDR-TB), repurposing FDA (U.S. Food and Drug Administration) -approved drugs for...
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Article
Open AccessCrim1 has cell-autonomous and paracrine roles during embryonic heart development
The epicardium has a critical role during embryonic development, contributing epicardium-derived lineages to the heart, as well as providing regulatory and trophic signals necessary for myocardial development....
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Chapter and Conference Paper
CMDragons 2015: Coordinated Offense and Defense of the SSL Champions
The CMDragons Small Size League (SSL) team won all of its 6 games at RoboCup 2015, scoring a total of 48 goals and conceding 0. This paper presents the core coordination algorithms in offense and defense that ...
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Chapter and Conference Paper
Iterative Snap** of Odometry Trajectories for Path Identification
An increasing number of mobile devices are capable of automatically sensing and recording rich information about the surrounding environment. Spatial locations of such data can help to better learn about the e...
