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Article
Open AccessCollagen type IV alpha 1 chain (COL4A1) expression in the develo** human lung
Collagen type IV alpha 1 chain (COL4A1) in the basement membrane is an important component during lung development, as suggested from animal models where COL4A1 has been shown to regulate alveolarization and a...
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Article
Open AccessPaneth cell proteins DEFA6 and GUCA2A as tissue markers in necrotizing enterocolitis
Previous studies suggest that Paneth cells are involved in NEC development. Defensin alpha 6 (DEFA6) and guanylate cyclase activator 2A (GUCA2A) are selective protein markers of Paneth cells. The objective was...
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Article
Established severe BPD: is there a way out? Change of ventilatory paradigms
Improved survival of extremely preterm newborn infants has increased the number of infants at risk for develo** bronchopulmonary dysplasia (BPD). Despite efforts to prevent BPD, many of these infants still d...
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Article
Modes and strategies for providing conventional mechanical ventilation in neonates
Neonatal respiratory failure is a common and serious clinical problem which in a considerable proportion of infants requires invasive mechanical ventilation. The basic goal of mechanical ventilation is to rest...
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Article
Open AccessThe value of autopsy in preterm infants at a Swedish tertiary neonatal intensive care unit 2002–2018
Reliable data on causes of death (COD) in preterm infants are needed to assess perinatal care and current clinical guidelines. In this retrospective observational analysis of all deceased preterm infants born ...
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Article
CD44 and RHAMM expression patterns in the human develo** lung
The hyaluronan (HA) receptors CD44 and RHAMM (CD168) are involved in cellular proliferation, differentiation, and motility. As previously investigated, HA and RHAMM expression in human neonatal lungs correlate...
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Article
Insights image for exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22–27 weeks’ gestation
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Article
Exploration of potential biochemical markers for persistence of patent ductus arteriosus in preterm infants at 22–27 weeks’ gestation
Early identification of infants at risk for complications from patent ductus arteriosus (PDA) may improve treatment outcomes. The aim of this study was to identify biochemical markers associated with persisten...
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Article
Reduced rate of treated retinopathy of prematurity after implementing lower oxygen saturation targets
To evaluate an implementation of lower oxygen saturation targets with retinopathy of prematurity (ROP) as primary outcome, in infants at the lowest extreme of prematurity.
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Article
Oscillatory respiratory mechanics on the first day of life improves prediction of respiratory outcomes in extremely preterm newborns
We aimed to evaluate if lung mechanics measured by forced oscillatory technique (FOT) during the first day of life help identify extremely low gestational age newborns (ELGANs) at risk of prolonged mechanical ...
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Article
Outcomes following a comprehensive versus a selective approach for infants born at 22 weeks of gestation
To examine outcomes at two institutions with different approaches to care among infants born at 22 weeks of gestation.
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Article
Open AccessMaintained inspiratory activity during proportional assist ventilation in surfactant-depleted cats early after surfactant instillation: phrenic nerve and pulmonary stretch receptor activity
Inspiratory activity is a prerequisite for successful application of patient triggered ventilation such as proportional assist ventilation (PAV). It has recently been reported that surfactant instillation incr...
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Article
Open AccessInhibition of breathing after surfactant depletion is achieved at a higher arterial PCO2 during ventilation with liquid than with gas
Inhibition of phrenic nerve activity (PNA) can be achieved when alveolar ventilation is adequate and when stretching of lung tissue stimulates mechanoreceptors to inhibit inspiratory activity. During mechanica...
