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Open AccessNew tuberculosis vaccines in India: modelling the potential health and economic impacts of adolescent/adult vaccination with M72/AS01E and BCG-revaccination
India had an estimated 2.9 million tuberculosis cases and 506 thousand deaths in 2021. Novel vaccines effective in adolescents and adults could reduce this burden. M72/AS01E and BCG-revaccination have recently co...
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Open AccessFeasibility of novel adult tuberculosis vaccination in South Africa: a cost-effectiveness and budget impact analysis
Early trials of novel vaccines against tuberculosis (TB) in adults have suggested substantial protection against TB. However, little is known about the feasibility and affordability of rolling out such vaccine...
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Open AccessCorrection to: The epidemiologic impact and cost-effectiveness of new tuberculosis vaccines on multidrug-resistant tuberculosis in India and China
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Open AccessCost-effectiveness of routine adolescent vaccination with an M72/AS01E-like tuberculosis vaccine in South Africa and India
The M72/AS01E tuberculosis vaccine showed 50% (95%CI: 2–74%) efficacy in a phase 2B trial in preventing active pulmonary tuberculosis disease, but potential cost-effectiveness of adolescent immunisation is unknow...
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Open AccessThe impact of blood transcriptomic biomarker targeted tuberculosis preventive therapy in people living with HIV: a mathematical modelling study
Tuberculosis (TB) preventive therapy is recommended for all people living with HIV (PLHIV). Despite the elevated risk of TB amongst PLHIV, most of those eligible for preventive therapy would never develop TB. ...
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Open AccessImpact of the Covid-19 epidemic and related social distancing regulations on social contact and SARS-CoV-2 transmission potential in rural South Africa: analysis of repeated cross-sectional surveys
South Africa implemented rapid and strict physical distancing regulations to minimize SARS-CoV-2 epidemic spread. Evidence on the impact of such measures on interpersonal contact in rural and lower-income sett...
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Open AccessThe epidemiologic impact and cost-effectiveness of new tuberculosis vaccines on multidrug-resistant tuberculosis in India and China
Despite recent advances through the development pipeline, how novel tuberculosis (TB) vaccines might affect rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB) is unknown. We investigated the...
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Open AccessThe predicted impact of tuberculosis preventive therapy: the importance of disease progression assumptions
Following infection with Mycobacterium tuberculosis (M.tb), individuals may rapidly develop tuberculosis (TB) disease or enter a “latent” infection state with a low risk of progression to disease. Mathematical mo...
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Open AccessPotential population level impact on tuberculosis incidence of using an mRNA expression signature correlate-of-risk test to target tuberculosis preventive therapy
Achieving the WHO End-Tuberculosis (TB) targets requires approaches to prevent progression to TB among individuals with Mycobacterium tuberculosis (M.tb) infection. Effective preventive therapy (PT) exists, but c...
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Open AccessMycobacterium tuberculosis transmission in an ethnically-diverse high incidence region in England, 2007–11
Transmission patterns in high tuberculosis incidence areas in England are poorly understood but need elucidating to focus contact tracing. We study transmission within and between age, ethnic and immigrant gro...
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Article
Open AccessCorrection to: Small contribution of gold mines to the ongoing tuberculosis epidemic in South Africa: a modeling-based study
The original article [1] did not contain comprehensive information regarding two authors’ affiliations that may be considered a potential competing interest.
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Article
Open AccessUsing vaccine Immunostimulation/Immunodynamic modelling methods to inform vaccine dose decision-making
Unlike drug dose optimisation, mathematical modelling has not been applied to vaccine dose finding. We applied a novel Immunostimulation/Immunodynamic mathematical modelling framework to translate multi-dose T...
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Open AccessInvestigating the impact of TB case-detection strategies and the consequences of false positive diagnosis through mathematical modelling
Increasing case notifications is one of the top programmatic priorities of National TB Control Programmes (NTPs). To find more cases, NTPs often need to consider expanding TB case-detection activities to popul...
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Open AccessTransmission events revealed in tuberculosis contact investigations in London
Contact tracing is a key part of tuberculosis prevention and care, aiming to hasten diagnosis and prevent transmission. The proportion of case-contact pairs for which recent transmission occurred and the typic...
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Open AccessSmall contribution of gold mines to the ongoing tuberculosis epidemic in South Africa: a modeling-based study
Gold mines represent a potential hotspot for Mycobacterium tuberculosis (Mtb) transmission and may be exacerbating the tuberculosis (TB) epidemic in South Africa. However, the presence of multiple factors complic...
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Open AccessAn explanation for the low proportion of tuberculosis that results from transmission between household and known social contacts
We currently have little idea where Mycobacterium tuberculosis (Mtb) transmission occurs in high incidence settings. Molecular studies suggest that only around 8–19% of transmission to adults occurs within-househ...
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Article
Open AccessImproving ART programme retention and viral suppression are key to maximising impact of treatment as prevention – a modelling study
UNAIDS calls for fewer than 500,000 new HIV infections/year by 2020, with treatment-as-prevention being a key part of their strategy for achieving the target. A better understanding of the contribution to tran...
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Open AccessUniversal test, treat, and keep: improving ART retention is key in cost-effective HIV control in Uganda
With ambitious new UNAIDS targets to end AIDS by 2030, and new WHO treatment guidelines, there is increased interest in the best way to scale-up ART coverage. We investigate the cost-effectiveness of various A...
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Open AccessThe potential impact of BCG vaccine supply shortages on global paediatric tuberculosis mortality
The Bacillus Calmette-Guérin (BCG) vaccine is provided to over 100 million neonates annually to protect against childhood tuberculosis (TB). Recent BCG manufacturing interruptions highlight global supply risks...
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A Systematic Review of Published Respondent-Driven Sampling Surveys Collecting Behavioral and Biologic Data
Reporting key details of respondent-driven sampling (RDS) survey implementation and analysis is essential for assessing the quality of RDS surveys. RDS is both a recruitment and analytic method and, as such, i...
