7 Result(s)
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Richard D. Palmiter
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessDevelopment of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release
Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide with key regulatory functions in several central behavioral processes including motivation, stress, feeding, and sleep. The func...
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Article
Open AccessParabrachial tachykinin1-expressing neurons involved in state-dependent breathing control
Breathing is regulated automatically by neural circuits in the medulla to maintain homeostasis, but breathing is also modified by behavior and emotion. Mice have rapid breathing patterns that are unique to the...
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Article
Open AccessTopographic representation of current and future threats in the mouse nociceptive amygdala
Adaptive behaviors arise from an integration of current sensory context and internal representations of past experiences. The central amygdala (CeA) is positioned as a key integrator of cognitive and affective...
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Article
Open AccessSatb2 neurons in the parabrachial nucleus mediate taste perception
The neural circuitry mediating taste has been mapped out from the periphery to the cortex, but genetic identity of taste-responsive neurons has remained elusive. Here, we describe a population of neurons in th...
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Article
Open AccessOrgan-specific, multimodal, wireless optoelectronics for high-throughput phenoty** of peripheral neural pathways
The vagus nerve supports diverse autonomic functions and behaviors important for health and survival. To understand how specific components of the vagus contribute to behaviors and long-term physiological effe...
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Article
Open AccessConditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson’s disease-like non-motor symptoms without loss of dopamine neurons
Reduction of mitochondrial complex I activity is one of the major hypotheses for dopaminergic neuron death in Parkinson’s disease. However, reduction of complex I activity in all cells or selectively in dopami...
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Article
Open AccessGenetically and functionally defined NTS to PBN brain circuits mediating anorexia
The central nervous system controls food consumption to maintain metabolic homoeostasis. In response to a meal, visceral signals from the gut activate neurons in the nucleus of the solitary tract (NTS) via the...
