38 Result(s)
within
Richard D. Palmiter
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessDevelopment of a genetically encoded sensor for probing endogenous nociceptin opioid peptide release
Nociceptin/orphanin-FQ (N/OFQ) is a recently appreciated critical opioid peptide with key regulatory functions in several central behavioral processes including motivation, stress, feeding, and sleep. The func...
-
Article
Open AccessParabrachial tachykinin1-expressing neurons involved in state-dependent breathing control
Breathing is regulated automatically by neural circuits in the medulla to maintain homeostasis, but breathing is also modified by behavior and emotion. Mice have rapid breathing patterns that are unique to the...
-
Article
Open AccessTopographic representation of current and future threats in the mouse nociceptive amygdala
Adaptive behaviors arise from an integration of current sensory context and internal representations of past experiences. The central amygdala (CeA) is positioned as a key integrator of cognitive and affective...
-
Article
Intercalated amygdala clusters orchestrate a switch in fear state
Adaptive behaviour necessitates the formation of memories for fearful events, but also that these memories can be extinguished. Effective extinction prevents excessive and persistent reactions to perceived thr...
-
Article
Open AccessSatb2 neurons in the parabrachial nucleus mediate taste perception
The neural circuitry mediating taste has been mapped out from the periphery to the cortex, but genetic identity of taste-responsive neurons has remained elusive. Here, we describe a population of neurons in th...
-
Article
Open AccessOrgan-specific, multimodal, wireless optoelectronics for high-throughput phenoty** of peripheral neural pathways
The vagus nerve supports diverse autonomic functions and behaviors important for health and survival. To understand how specific components of the vagus contribute to behaviors and long-term physiological effe...
-
Article
Encoding of danger by parabrachial CGRP neurons
Animals must respond to various threats to survive. Neurons that express calcitonin gene-related peptide in the parabrachial nucleus (CGRPPBN neurons) relay sensory signals that contribute to satiation and pain-i...
-
Article
Open AccessConditional deletion of Ndufs4 in dopaminergic neurons promotes Parkinson’s disease-like non-motor symptoms without loss of dopamine neurons
Reduction of mitochondrial complex I activity is one of the major hypotheses for dopaminergic neuron death in Parkinson’s disease. However, reduction of complex I activity in all cells or selectively in dopami...
-
Article
Bone-derived hormone suppresses appetite
The glycoprotein lipocalin 2 is released from the bones of mice in a nutrient-dependent manner and binds to receptors in the brain to suppress appetite. This is the first example of bone-derived signals mediat...
-
Article
Open AccessGenetically and functionally defined NTS to PBN brain circuits mediating anorexia
The central nervous system controls food consumption to maintain metabolic homoeostasis. In response to a meal, visceral signals from the gut activate neurons in the nucleus of the solitary tract (NTS) via the...
-
Article
The paraventricular thalamus controls a central amygdala fear circuit
Inhibiting projections from the paraventricular nucleus of the thalamus to a specific division of the amygdala prevents fear conditioning in mice, indicating an important role for the thalamus–amygdala circuit...
-
Article
Genetic identification of a neural circuit that suppresses appetite
A neural circuit from the parabrachial nucleus to the central nucleus of the amygdala mediates appetite suppression.
-
Article
Transient activation of specific neurons in mice by selective expression of the capsaicin receptor
The ability to control the electrical activity of a neuronal subtype is a valuable tool in deciphering the role of discreet cell populations in complex neural circuits. Recent techniques that allow remote cont...
-
Article
Deciphering a neuronal circuit that mediates appetite
Dissection of the neuronal circuit driving feeding behaviour in mice shows that suppression of the parabrachial nucleus protects against aphagia and promotes weight gain, and also that the parabrachial nucleus...
-
Article
Morphine reward in dopamine-deficient mice
People take drugs of abuse, at least initially, because of their pleasurable effects; later on, chronic use can lead to addiction. There is a large literature supporting the idea that dopamine release is respo...
-
Article
Leptin-regulated endocannabinoids are involved in maintaining food intake
Leptin is the primary signal through which the hypothalamus senses nutritional state and modulates food intake and energy balance1. Leptin reduces food intake by upregulating anorexigenic (appetite-reducing) neur...
-
Article
Ethanol consumption and resistance are inversely related to neuropeptide Y levels
Genetic linkage analysis of rats that were selectively bred for alcohol preference identified a chromosomal region that includes the neuropeptide Y (NPY) gene1. Alcohol-preferring rats have lower levels of NPY in...
-
Article
Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline
Adrenaline and noradrenaline, the main effectors of the sympathetic nervous system and adrenal medulla, respectively, are thought to control adiposity and energy balance through several mechanisms. They promot...
-
Article
Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y
NEUROPEPTIDE Y (NPY), a 36-amino-acid transmitter distributed throughout the nervous system1,2, is thought to function as a central stimulator of feeding behaviour1–4. NPY has also been implicated in the modulat...
-
Article
Targeted disruption of the tyrosine hydroxylase gene reveals that catecholamines are required for mouse fetal development
TYROSINE hydroxylase catalyses the initial, rate-limiting step in the catecholamine biosynthetic pathway. Catecholamines, which include dopamine, noradrenaline, and adrenaline, are important neurotransmitters ...
