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Article
Open AccessDisruption of lysosomal proteolysis in astrocytes facilitates midbrain organoid proteostasis failure in an early-onset Parkinson’s disease model
Accumulation of advanced glycation end products (AGEs) on biopolymers accompanies cellular aging and drives poorly understood disease processes. Here, we studied how AGEs contribute to development of early ons...
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Article
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes
APOE4 is the strongest genetic risk factor for Alzheimer’s disease1–3. However, the effects of APOE4 on the human brain are not fully understood, limiting opportunities to develop targeted therapeutics for indivi...
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Article
Open AccessNanoparticle-mediated selective Sfrp-1 silencing enhances bone density in osteoporotic mice
Osteoporosis (OP) is characterized by a loss in bone mass and mineral density. The stimulation of the canonical Wnt/β-catenin pathway has been reported to promote bone formation, this pathway is controlled by ...
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Article
EPR Dosimetry in Human Fingernails: Investigation of the Origin of the Endogenous Signal and Implications for Estimating Dose from Nail Signals
Human nails have been studied for many years for potential use for dosimetry, based on the EPR signals induced by ionizing radiation, but a fully validated protocol to measure doses retrospectively has not yet...
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Article
Open AccessOptimized hip-knee-ankle exoskeleton assistance reduces the metabolic cost of walking with worn loads
Load carriage is common in a wide range of professions, but prolonged load carriage is associated with increased fatigue and overuse injuries. Exoskeletons could improve the quality of life of these profession...
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Article
Open AccessOptimized hip–knee–ankle exoskeleton assistance at a range of walking speeds
Autonomous exoskeletons will need to be useful at a variety of walking speeds, but it is unclear how optimal hip–knee–ankle exoskeleton assistance should change with speed. Biological joint moments tend to inc...
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Article
Open AccessOrganotypic culture as a research and preclinical model to study uterine leiomyomas
Organotypic cultures of tissue slices have been successfully established in lung, prostate, colon, gastric and breast cancer among other malignancies, but until now an ex vivo model based on tissue slices has not...
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Article
Open AccessReduced order models for thermally coupled low Mach flows
In this paper we present a collection of techniques used to formulate a projection-based reduced order model (ROM) for zero Mach limit thermally coupled Navier–Stokes equations. The formulation derives from a ...
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Article
In situ gel-forming system for dual BMP-2 and 17β-estradiol controlled release for bone regeneration in osteoporotic rats
The aim of this study was to evaluate the bone regeneration capacity of a Pluronic® F127 (P)-Tetronic®1307 (T) and α-cyclodextrin (CD) supramolecular gel (P-T-CD) in a 11/7/7 ratio containing BMP-2 and 17β-est...
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Article
A platelet derived growth factor delivery system for bone regeneration
platelet derived growth factor (PDGF) was formulated in a calcium phosphate/biodegradable polymer system for local and controlled delivery to enhance bone regeneration. Implants with a porosity of 67 %, compos...
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Article
Long-Term Follow-Up of Iliac Wallstents
We evaluated the long-term results of the iliac artery stent placement for the treatment of patients with intermittent claudication. From November 1988 to December 1998, 303 legs were treated with metal stents...
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Article
Treatment of Complete and Partial Obstruction of the Nasolacrimal System with Polyurethane Stents: Initial Experience
Purpose: To present our experience in the treatment of nasolacrimal occlusion by means of polyurethane stents.
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Article
Retrieval of Migrated Colonic Stents from the Rectum
Palliative stenting of malignant colonic obstruction may be complicated by stent migration. Stents that migrate into the rectum cannot be passed with bowel movements and frequently cause obstruction. We prese...
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Article
Transjugular liver biopsy: A review of 77 biopsies using a spring-propelled cutting needle (biopsy gun)
Seventy-seven transjugular liver biopsies were performed with a coaxial, spring-loaded, 18-gauge cutting needle, the Biopty gun (Bard Biopsy System, Covington, GA, USA) on consecutive patients between July 199...
