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  1. No Access

    Article

    Anti-T Lymphocyte Globulin (ATG) Induces Generation of Regulatory T Cells, at Least Part of Them Express Activated CD44

    We show here that the anti-T lymphocyte immunoglobulin (ATG) can induce Treg cells following 24-h incubation in human peripheral blood mononuclear cells (PBMCs). The ATG-induced Treg cells express known cell s...

    Orly Shimony, Arnon Nagler, Yechiel N. Gellman… in Journal of Clinical Immunology (2012)

  2. No Access

    Article

    Immunotherapy in high-risk chemotherapy-resistant patients with metastatic solid tumors and hematological malignancies using intentionally mismatched donor lymphocytes activated with rIL-2: a phase I study

    The feasibility and safety of immunotherapy mediated by intentionally mismatched rIL-2 activated killer lymphocytes (IMAK) with no prior stem cell engraftment was investigated in patients with advanced chemoth...

    Shimon Slavin, Aliza Ackerstein, Reuven Or… in Cancer Immunology, Immunotherapy (2010)

  3. Article

    Open Access

    Neuroblastoma Cell Death is Induced by Inorganic Arsenic Trioxide (As2O3) and Inhibited by a Normal Human Bone Marrow Cell-Derived Factor

    Three phenotypically distinct cell types are present in human neuroblastomas (NB) and NB cell lines: I-type stem cells, N-type neuroblastic precursors, and S-type Schwannian/melanoblastic precursors. The stimu...

    Benjamin Gesundheit, Lea Malach, Reuven Or, Talia Hahn in Cancer Microenvironment (2008)

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    Article

    Interleukin 2 regulation following semi-allogeneic bone marrow transplantation in mice

    Success of allogeneic and autologous bone marrow transplantation (BMT) is hampered by susceptibility to infection during the first two post-treatment years. Further, in treating malignant diseases, impaired an...

    Ali Abdul-Hai, Arie Ben-Yehuda, Haya Galsky… in Cancer Immunology, Immunotherapy (2006)

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    Article

    Mycophenolate mofetil does not suppress the graft-versus-leukemia effect or the activity of lymphokine-activated killer (LAK) cells in a murine model

    Background: Graft-versus-leukemia (GVL) effect is an essential component in the course of allogeneic stem cell transplantation (SCT). However, both prevention and treatment of established graft-versus-host dis...

    Michael Y. Shapira, Ester Hirshfeld, Lola Weiss… in Cancer Immunology, Immunotherapy (2005)

  6. No Access

    Article

    Allogeneic stem cell transplantation for the treatment of diseases associated with a deficiency in bone marrow products

    Our understanding of the pathophysiology of hematopoietic failure associated syndromes led to the developmental of potentially curative procedures for the treatment of many diseases including Severe aplastic a...

    Reuven Or, Memet Aker, Michael Yechiel Shapira… in Springer Seminars in Immunopathology (2004)

  7. No Access

    Article

    Immunotherapy of murine leukemia following non-myeloablative conditioning with naïve or G-CSF mobilized blood or bone marrow stem cells

    Allogeneic stem cell transplantation (SCT) is the treatment of choice for a large number of hematologic malignancies. Its major advantage over conventional chemotherapy lies in the graft-versus-leukemia (GVL) ...

    Lola Weiss, Reuven Or, Shimon Slavin, Ella Naparstek… in Cancer Immunology, Immunotherapy (2004)

  8. No Access

    Article

    Topical tacrolimus—a novel treatment alternative for cutaneous chronic graft-versus-host disease

    Graft-versus-host disease (GVHD) may be resistant to accepted treatments. Therefore, the aim of the present preliminary study was to evaluate the efficacy of topical treatment with tacrolimus, an immunosuppres...

    Sharon Elad, Reuven Or, Igor Resnick, Michael Y. Shapira in Transplant International (2003)

  9. No Access

    Article

    Treatment of Leukemia by Alloreactive Lymphocytes and Nonmyeloablative Stem Cell Transplantation

    Allogeneic bone marrow or blood stem cell transplantation (BMT) represents an important therapeutic tool for treatment of otherwise incurable malignant and nonmalignant diseases, especially acute and chronic l...

    Shimon Slavin, Arnon Nagler, Michael Y. Shapira… in Journal of Clinical Immunology (2002)