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  1. No Access

    Article

    Dynamic network-guided CRISPRi screen identifies CTCF-loop-constrained nonlinear enhancer gene regulatory activity during cell state transitions

    Comprehensive enhancer discovery is challenging because most enhancers, especially those contributing to complex diseases, have weak effects on gene expression. Our gene regulatory network modeling identified ...

    Renhe Luo, Jielin Yan, ** Woo Oh, Wang **, Dustin Shigaki, Wilfred Wong… in Nature Genetics (2023)

  2. No Access

    Article

    CRISPR screening uncovers a central requirement for HHEX in pancreatic lineage commitment and plasticity restriction

    The pancreas and liver arise from a common pool of progenitors. However, the underlying mechanisms that drive their lineage diversification from the foregut endoderm are not fully understood. To tackle this qu...

    Dapeng Yang, Hyunwoo Cho, Zakieh Tayyebi, Abhijit Shukla, Renhe Luo… in Nature Cell Biology (2022)

  3. No Access

    Article

    Genome-scale screens identify JNK–JUN signaling as a barrier for pluripotency exit and endoderm differentiation

    Human embryonic stem cells (ESCs) and human induced pluripotent stem cells hold great promise for cell-based therapies and drug discovery. However, homogeneous differentiation remains a major challenge, highli...

    Qing V. Li, Gary Dixon, Nipun Verma, Bess P. Rosen, Miriam Gordillo… in Nature Genetics (2019)