-
Article
Open AccessAntibacterial activity of the antimicrobial peptide PMAP-36 in combination with tetracycline against porcine extraintestinal pathogenic Escherichia coli in vitro and in vivo
The increase in the emergence of antimicrobial resistance has led to great challenges in controlling porcine extraintestinal pathogenic Escherichia coli (ExPEC) infections. Combinations of antimicrobial peptides ...
-
Chapter
Exotoxins of Staphylococcus aureus
Staphylococcus aureus produces a variety of exotoxins, which are important virulence factors for S. aureus-related diseases. Representatively, staphylococcal enterotoxins induce staphylococcal food-born poisoning...
-
Article
Open AccessRACK1 mediates NLRP3 inflammasome activation during Pasteurella multocida infection
Pasteurella multocida is a gram-negative bacterium that causes serious diseases in a wide range of animal species. Inflammasomes are intracellular multimolecular protein complexes that play a critical role in ho...
-
Article
Open AccessThe protective role of chicken cathelicidin-1 against Streptococcus suis serotype 2 in vitro and in vivo
Streptococcus suis serotype 2 (SS2) is an important zoonotic pathogen with the characteristics of high mortality and morbidity, which brings great challenges to prevent and control epidemic disease in the swine i...
-
Article
Open AccessThe important role of NLRP6 inflammasome in Pasteurella multocida infection
Pasteurella multocida (P. multocida) can cause severe respiratory disease in cattle, resulting in high mortality and morbidity. Inflammasomes are multiprotein complexes in the cytoplasm that recognize pathogens a...
-
Article
Open AccessPseudomonas aeruginosa biofilm dispersion by the mouse antimicrobial peptide CRAMP
Pseudomonas aeruginosa (P. aeruginosa) is a known bacterium that produces biofilms and causes severe infection. Furthermore, P. aeruginosa biofilms are extremely difficult to eradicate, leading to the developmen...
-
Article
Open AccessChicken cathelicidin-2 promotes NLRP3 inflammasome activation in macrophages
Chicken cathelicidin-2 (CATH-2) as a host defense peptide has been identified to have potent antimicrobial and immunomodulatory activities. Here, we reported the mechanism by which CATH-2 modulates NLRP3 infla...
-
Article
Open AccessUpdate on molecular diversity and multipathogenicity of staphylococcal superantigen toxins
Staphylococcal superantigen (SAg) toxins are the most notable virulence factors associated with Staphylococcus aureus, which is a pathogen associated with serious community and hospital acquired infections in hum...
-
Article
Open AccessGenotypic characterization and antimicrobial resistance profile of Salmonella isolated from chicken, pork and the environment at abattoirs and supermarkets in Chongqing, China
Salmonella is one of the most important foodborne pathogens, causing outbreaks of human salmonellosis worldwide. Owing to large scales of consumption markets, pork and poultry that contaminated by Salmonella coul...
-
Article
First detection and genotypic analysis of goat enzootic nasal tumor virus 2 in Chongqing, China
Enzootic nasal adenocarcinoma (ENA) of goats, characterized by transformation of epithelial cells of the ethmoid turbinates, is caused by enzootic nasal tumor virus 2 (ENTV-2). ENTV-2 belongs to the genus Betaret...
-
Article
Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity
The adaptor ASC is required for caspase-1 activation via the NLRP3 and AIM2 inflammasomes. Mitsuyama and colleagues show that signaling dependent on the kinases Syk and Jnk controls ASC speck formation through...
