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Physiogenomic resources for rat models of heart, lung and blood disorders
Cardiovascular disorders are influenced by genetic and environmental factors. The TIGR rodent expression web-based resource (TREX) contains over 2,200 microarray hybridizations, involving over 800 animals from...
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Article
Addendum: Standardizing global gene expression analysis between laboratories and across platforms
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Article
Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12
Activated forms of Ras family members are prevalent in many cancers where Ras mutants transduce signals essential for transformation, angiogenesis, invasion and metastasis. As a cancer progression model, we us...
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Article
Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes
The superfamily of small GTP-binding proteins has expanded dramatically in recent years. The Ras family has long been associated with signaling pathways contributing to normal and aberrant cell growth, while R...
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Article
Assessing unmodified 70-mer oligonucleotide probe performance on glass-slide microarrays
Long oligonucleotide microarrays are potentially more cost- and management-efficient than cDNA microarrays, but there is little information on the relative performance of these two probe types. The feasibility...
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Article
Identification of Src transformation fingerprint in human colon cancer
We used a classical rodent model of transformation to understand the transcriptional processes, and hence the molecular and cellular events a given cell undergoes when progressing from a normal to a transforme...
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Use of the Rat Gene Index to examine gene expression patterns from Src-transformed rat fibroblasts that exhibit broad differences in metastatic potential