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Open AccessGenome-wide characterization of circulating metabolic biomarkers
Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1–7. This detailed knowledge of the genetic determinants of systemic me...
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Article
Open AccessGenome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population
While 1–2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~13–38%) experience subclinical obsessive-compulsive symptoms (OCS) during their life. To...
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Open AccessLongitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins
The influence of genetics and environment on the association of the plasma proteome with body mass index (BMI) and changes in BMI remains underexplored, and the links to other omics in these associations remai...
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Open AccessIntegrative Multi-omics Analysis of Childhood Aggressive Behavior
This study introduces and illustrates the potential of an integrated multi-omics approach in investigating the underlying biology of complex traits such as childhood aggressive behavior. In 645 twins (cases = ...
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Open AccessCorrection: Meta-analysis of genome-wide association studies of hoarding symptoms in 27,537 individuals
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Article
Open AccessA genetically informed prediction model for suicidal and aggressive behaviour in teens
Suicidal and aggressive behaviours cause significant personal and societal burden. As risk factors associated with these behaviours frequently overlap, combined approaches in predicting the behaviours may be u...
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Article
Open AccessMeta-analysis of genome-wide association studies of hoarding symptoms in 27,651 individuals
Hoarding Disorder (HD) is a mental disorder characterized by persistent difficulties discarding or parting with possessions, often resulting in cluttered living spaces, distress, and impairment. Its etiology i...
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Article
Open AccessDNA methylation in peripheral tissues and left-handedness
Handedness has low heritability and epigenetic mechanisms have been proposed as an etiological mechanism. To examine this hypothesis, we performed an epigenome-wide association study of left-handedness. In a m...
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Open AccessContinuity of Genetic Risk for Aggressive Behavior Across the Life-Course
We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and ...
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Article
Open AccessImplementation and implications for polygenic risk scores in healthcare
Increasing amounts of genetic data have led to the development of polygenic risk scores (PRSs) for a variety of diseases. These scores, built from the summary statistics of genome-wide association studies (GWA...
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Article
Open AccessInvestigating the relationships between unfavourable habitual sleep and metabolomic traits: evidence from multi-cohort multivariable regression and Mendelian randomization analyses
Sleep traits are associated with cardiometabolic disease risk, with evidence from Mendelian randomization (MR) suggesting that insomnia symptoms and shorter sleep duration increase coronary artery disease risk...
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Open AccessAuthor Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Open AccessHeritability estimates for 361 blood metabolites across 40 genome-wide association studies
Metabolomics examines the small molecules involved in cellular metabolism. Approximately 50% of total phenotypic differences in metabolite levels is due to genetic variance, but heritability estimates differ a...
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Open AccessMetabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium
Telomere shortening has been associated with multiple age-related diseases such as cardiovascular disease, diabetes, and dementia. However, the biological mechanisms responsible for these associations remain l...
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Open AccessMetabolite ratios as potential biomarkers for type 2 diabetes: a DIRECT study
Circulating metabolites have been shown to reflect metabolic changes during the development of type 2 diabetes. In this study we examined the association of metabolite levels and pairwise metabolite ratios wit...
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Article
Identification of context-dependent expression quantitative trait loci in whole blood
Bastiaan Heijmans, Peter ’t Hoen, Lude Franke and colleagues describe a strategy to identify context-dependent expression quantitative trait loci (eQTLs). They apply their method to peripheral blood RNA–seq da...
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Article
Disease variants alter transcription factor levels and methylation of their binding sites
Peter 't Hoen, Lude Franke, Bastiaan Heijmans and colleagues present a combined analysis of methylome and transcriptome data from a large collection of whole-blood samples to infer the downstream effects of di...
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Open AccessGenome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA
Genome-wide association studies have identified numerous loci linked with complex diseases, for which the molecular mechanisms remain largely unclear. Comprehensive molecular profiling of circulating metabolit...
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Article
Open AccessHeritability, SNP- and Gene-Based Analyses of Cannabis Use Initiation and Age at Onset
Prior searches for genetic variants (GVs) implicated in initiation of cannabis use have been limited to common single nucleotide polymorphisms (SNPs) typed in HapMap samples. Denser SNPs are now available with...
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Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels
Metabolites are small molecules involved in cellular metabolism, which can be detected in biological samples using metabolomic techniques. Here we present the results of genome-wide association and meta-analys...
