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Article
Open AccessIs the future of peer review automated?
The rising rate of preprints and publications, combined with persistent inadequate reporting practices and problems with study design and execution, have strained the traditional peer review system. Automated ...
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Chapter
Quality in Non-GxP Research Environment
There has been increasing evidence in recent years that research in life sciences is lacking in reproducibility and data quality. This raises the need for effective systems to improve data integrity in the evo...
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Article
Open AccessAgmatine modulates spontaneous activity in neurons of the rat medial habenular complex—a relevant mechanism in the pathophysiology and treatment of depression?
The dorsal diencephalic conduction system connects limbic forebrain structures to monaminergic mesencephalic nuclei via a distinct relay station, the habenular complexes. Both habenular nuclei, the lateral as ...
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Chapter
Errors and Error Management in Biomedical Research
The authors put a much-needed focus on the validity of biomedical research results that has come under scrutiny. However, as they make clear, due to the complexity of the experiments involved, errors quite nat...
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Article
Microarray analysis of transcripts with elevated expressions in the rat medial or lateral habenula suggest fast GABAergic excitation in the medial habenula and habenular involvement in the regulation of feeding and energy balance
In vertebrates the “anti-reward-system” mainly is represented by the habenula and its medial (MHb) and especially lateral (LHb) complexes. Considerable knowledge has accumulated concerning subnuclear structure...
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Protocol
Behavioral Testing in Rodent Models of Stroke, Part I
For the past decades, experimental intervention showed therapeutic promise in animal models of stroke has largely failed to produce beneficial effects in human stroke patients. The difficulty in translating pr...
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Protocol
Region-Specific In Situ Hybridization-Guided Laser-Capture Microdissection on Postmortem Human Brain Tissue Coupled with Gene Expression Quantification
This chapter describes the procedure of in situ hybridization-guided laser-capture microdissection performed on postmortem human brain tissue. This procedure permits the precise collection of brain tissue with...
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Article
BKβ1 Subunits Contribute to BK Channel Diversity in Rat Hypothalamic Neurons
Large conductance Ca2+-activated BK channels are important regulators of action potential duration and firing frequency in many neurons. As the pore-forming subunits of BK channels are encoded by a single gene, c...
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Chapter
Microwave Atmospheric Sounding (Water Vapor and Liquid Water)
The ATSR microwave radiometer will be flown on-board the ERS-1 satellite, and wil be devoted to the measurement of atmospheric water vapour and liquid water content, with as main purpose the knowledge of atmos...
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Chapter
Microscopie électronique par balayage
Nous avons construit un microscope électronique à balayage utilisant des électrons primaires de faible énergie: 1.000 à 2.000 eV (1, 2). Le spot a une intensité de 10−10 Amp environ. Les électrons réfléchis inter...
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Chapter and Conference Paper
Microscopie à émission ionique négative
Nous avons utilisé les ions négatifs émis par l’impact d’ions positifs rapides sur une surface métallique pour former une image de cette surface (1).
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Chapter and Conference Paper
Microscopie électronique par balayage
Nous avons construit un microscope électronique à balayage utilisant des électrons primaires de faible énergie: 1.000 à 2.000 eV (1, 2). Le spot a une intensité de 10−10 Amp environ. Les électrons réfléchis inter...
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Chapter
Microscopie à émission ionique négative
Nous avons utilisé les ions négatifs émis par l’impact d’ions positifs rapides sur une surface métallique pour former une image de cette surface (1).
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Chapter
Reflexions- und Emissionsmikroskopie
The crystallographic structure, and hence the chemical composition of surfaces, is readily found by reflection electron diffraction, but the distribution of surface constituents and the fraction of the surface...
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Chapter
Elektronen- und Röntgen-Rastermikroskopie
Following the application by Castaing and Guinier (1) of the electron-optical techniques of electron microscopy to X-ray micro-analysis, a number of instruments (2–5) have been described in the literature. In 195...
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Article
Enhancement of the Sodium D Lines in the Twilight Sky Light
Prof. J. Cabannes, Prof. J. Dufay and J. Gauzit1 state that the twilight enhancement of the yellow radiation of the night sky announced by me2 was previously observed by Currie and Edwards at Chesterfield (Canada...
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Article
Possible Presence of Metastable Atoms of Nitrogen (2P) in the High Atmosphere
DURING a stay at the Tromsø Observatory, I studied systematically the spectrum of different forms of auroras (arcs, draperies, clouds, corona, etc.). One hundred spectrograms were thus obtained in the autumn o...
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Article
Sodium in the High Atmosphere
IN the spectrum of the sky at twilight, a yellow radiation was found very near the mean wave-length of the sodium D lines (λ = 5893 A.). This radiation is relatively strong, but its intensity decreases abruptly i...
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Article
Spectrum of Nitrogen and Atmospheric Pressure at High Altitudes
IN a series of experiments on the excitation of nitrogen bands by a controlled electronic bombardment, I have observed, as Dr. Kaplan did1, the great modifications of the spectrum which accompany any change in th...
