3 Result(s)
within
Rekha Rai
Life Sciences, general
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Article
Structural and functional analyses of the mammalian TIN2-TPP1-TRF2 telomeric complex
Telomeres are nucleoprotein complexes that play essential roles in protecting chromosome ends. Mammalian telomeres consist of repetitive DNA sequences bound by the shelterin complex. In this complex, the POT1-...
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Article
The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection
Rnf8 is an E3 ligase involved in the DNA damage response, adding ubiquitin moieties to histones H2A and H2AX at sites of DNA damage. Now Rnf8 is found to modify shelterin subunit Tpp1, and this is important fo...
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Article
A conserved motif within RAP1 has diversified roles in telomere protection and regulation in different organisms
Telomere protein RAP1 is found in organisms from yeast to mammals, but has different functions. Now the crystal structures of the RAP1 C-terminus (RCT) with its different interacting partners, together with fu...
