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Article
Circulating vitamin D and breast cancer risk: an international pooling project of 17 cohorts
Laboratory and animal research support a protective role for vitamin D in breast carcinogenesis, but epidemiologic studies have been inconclusive. To examine comprehensively the relationship of circulating 25-...
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Article
Open AccessCross-ancestry GWAS meta-analysis identifies six breast cancer loci in African and European ancestry women
Our study describes breast cancer risk loci using a cross-ancestry GWAS approach. We first identify variants that are associated with breast cancer at P < 0.05 from African ancestry GWAS meta-analysis (9241 ca...
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Article
Open AccessBody size and weight change over adulthood and risk of breast cancer by menopausal and hormone receptor status: a pooled analysis of 20 prospective cohort studies
Associations between anthropometric factors and breast cancer (BC) risk have varied inconsistently by estrogen and/or progesterone receptor (ER/PR) status. Associations between prediagnostic anthropometric fac...
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Article
Open AccessWhite blood cell DNA methylation and risk of breast cancer in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO)
Several studies have suggested that global DNA methylation in circulating white blood cells (WBC) is associated with breast cancer risk.
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Article
Open AccessA functionally significant SNP in TP53 and breast cancer risk in African-American women
A coding region polymorphism exists in the TP53 gene (Pro47Ser; rs1800371) in individuals of African descent, which reduces p53 tumor suppressor function in a mouse model. It has been unclear whether this functio...
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Article
Genetic variants in microRNA and microRNA biogenesis pathway genes and breast cancer risk among women of African ancestry
MicroRNAs (miRNA) regulate breast biology by binding to specific RNA sequences, leading to RNA degradation and inhibition of translation of their target genes. While germline genetic variations may disrupt som...
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Article
Open AccessFemale chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome
To investigate large structural clonal mosaicism of chromosome X, we analysed the SNP microarray intensity data of 38,303 women from cancer genome-wide association studies (20,878 cases and 17,425 controls) an...
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Article
Open AccessGenetic risk variants associated with in situ breast cancer
Breast cancer in situ (BCIS) diagnoses, a precursor lesion for invasive breast cancer, comprise about 20 % of all breast cancers (BC) in countries with screening programs. Family history of BC is considered on...
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Article
Open AccessA migrant study of pubertal timing and tempo in British-Bangladeshi girls at varying risk for breast cancer
Earlier menarche is related to subsequent breast cancer risk, yet international differences in the age and tempo of other pubertal milestones and their relationships with body mass index (BMI) are not firmly e...
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Article
Analgesic Use and Patterns of Estrogen Metabolism in Premenopausal Women
Analgesic use has been hypothesized to reduce the risk of some cancers, with inverse associations between analgesics and colon cancer, and suggestive inverse associations for breast cancer. Estrogen metabolite...
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Article
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry
Keri Monda, Kari North, Christopher Haiman and colleagues report a meta-analysis of GWAS for body mass index that is composed of 39,144 individuals of African ancestry, followed by further genoty** in 32,268...
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Article
Genome-wide association studies identify four ER negative–specific breast cancer risk loci
Montserrat Garcia-Closas and colleagues report a meta-analysis of three genome-wide association studies for estrogen receptor (ER)-negative breast cancer, including 4,193 ER-negative breast cancer cases and 35...
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Article
Open AccessGreen tea intake is associated with urinary estrogen profiles in Japanese-American women
Intake of green tea may reduce the risk of breast cancer; polyphenols in this drink can influence enzymes that metabolize estrogens, known causal factors in breast cancer etiology.
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Article
A genome-wide association study of breast cancer in women of African ancestry
Genome-wide association studies (GWAS) in diverse populations are needed to reveal variants that are more common and/or limited to defined populations. We conducted a GWAS of breast cancer in women of African ...
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Article
Body Size in Relation to Urinary Estrogens and Estrogen Metabolites (EM) Among Premenopausal Women during the Luteal Phase
Estrogen metabolism profiles may play an important role in the relationship between body size and breast carcinogenesis. Previously, we observed inverse associations between current body mass index (BMI) and p...
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Article
Urinary estrogens and estrogen metabolites and mammographic density in premenopausal women
Mammographic density is a strong and independent risk factor for breast cancer and is considered an intermediate marker of risk. The major predictors of premenopausal mammographic density, however, have yet to...
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Article
Alcohol, genetics and risk of breast cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial
We tested the hypothesis that genes involved in the alcohol oxidation pathway modify the association between alcohol intake and breast cancer. Subjects were women aged 55–74 at baseline from the screening arm ...
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Article
Detectable clonal mosaicism and its relationship to aging and cancer
Luis Pérez-Jurado, Stephen Chanock and colleagues detect clonal chromosomal abnormalities in peripheral blood or buccal samples from individuals in the general population. They show that the frequency of such ...
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Article
Fine map** of 14q24.1 breast cancer susceptibility locus
In the National Cancer Institute Cancer Genetic Markers of Susceptibility (CGEMS) genome-wide association study of breast cancer, a single nucleotide polymorphism (SNP) marker, rs999737, in the 14q24.1 interva...
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Article
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor–negative breast cancer
Christopher Haiman and colleagues report a genome-wide association study for estrogen receptor (ER)-negative breast cancer in women of African and European ancestry. They identify a variant at the TERT-CLPTM1L lo...
