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Article
Open AccessFive-Year Outcome of Laparoscopic Fundoplication in Pediatric GERD Patients: a Multicenter, Prospective Cohort Study
Gastroesophageal reflux disease (GERD) is a common disease in children. When drug treatment fails, laparoscopic anti-reflux surgery (LARS) is considered. Short-term follow-up studies report high success rates;...
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Article
Open AccessAnti-Müllerian hormone levels and risk of type 2 diabetes in women
Given its role in ovarian follicle development, circulating anti-Müllerian hormone (AMH) is considered to be a marker of reproductive ageing. Although accelerated reproductive ageing has been associated with a...
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Article
Open AccessHealth-related quality of life in children after laparoscopic gastrostomy placement
A gastrostomy placement (GP) is an established treatment to provide enteral feeding in pediatric patients with feeding difficulties aiming to improve nutritional status and health-related quality of life (HRQo...
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Article
Open AccessEffectiveness of endoscopic totally extraperitoneal (TEP) hernia correction for clinically occult inguinal hernia (EFFECT): study protocol for a randomized controlled trial
Groin pain is a frequent complaint in surgical practice with an inguinal hernia being at the top of the differential diagnosis. The majority of inguinal hernias can be diagnosed clinically. However, patients w...
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Article
Open AccessLaparoscopic antireflux surgery increases health-related quality of life in children with GERD
Improving health-related quality of life (HRQoL) is increasingly recognized as an essential part of patient care outcome. Little is known about the effect of laparoscopic antireflux surgery (LARS) on the HRQoL...
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Article
Open AccessThe Effect of Gastrostomy Placement on Gastric Function in Children: a Prospective Cohort Study
A gastrostomy placement is frequently performed in pediatric patients who require long-term enteral tube feeding. Unfortunately, postoperative complications such as leakage, feeding intolerance, and gastroesop...
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Article
Open AccessDiabetes self-management education after pre-selection of patients: design of a randomised controlled trial
Many self-management programs have been developed so far. Their effectiveness varies. The program ‘Beyond Good Intentions’ (BGI) is based on proactive co** and has proven to be (cost-) effective in achieving...
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Article
Open AccessThe impact of chronic fatigue syndrome on cognitive functioning in adolescents
Chronic fatigue syndrome (CFS) is characterized by persistent fatigue and severe disability. Most adolescent patients report attention and concentration problems, with subsequent poor performance at school. Th...
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Article
Open AccessTailored support for type 2 diabetes patients with an acute coronary event after discharge from hospital – design and development of a randomised controlled trial
Type 2 diabetes mellitus patients with an acute coronary event (ACE) experience decreased quality of life and increased distress. According to the American Diabetes Association, discharge from the hospital is ...
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Article
Open AccessEffect of early intensive multifactorial therapy compared with routine care on self-reported health status, general well-being, diabetes-specific quality of life and treatment satisfaction in screen-detected type 2 diabetes mellitus patients (ADDITION-Europe): a cluster-randomised trial
The study aimed to examine the effects of intensive treatment (IT) vs routine care (RC) on patient-reported outcomes after 5 years in screen-detected diabetic patients.
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Article
Open AccessMorphological Features in Children with Autism Spectrum Disorders: A Matched Case–Control Study
This study was designed to examine morphological features in a large group of children with autism spectrum disorder versus normal controls. Amongst 421 patients and 1,007 controls, 224 matched pairs were crea...
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Article
Open AccessAre physical symptoms among survivors of a disaster presented to the general practitioner? A comparison between self-reports and GP data
Most studies examining medically unexplained symptoms (MUS) have been performed in primary or secondary care and have examined symptoms for which patients sought medical attention. Disasters are often describe...
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Article
Health-related quality of life and mental health problems after a disaster: Are chronically ill survivors more vulnerable to health problems?
Studies have shown that the chronically ill are at higher risk for reduced health-related quality of life (HRQL) and for mental health problems. A combination with traumatic events might increase this risk. Th...
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Article
Determinants of Response in a Longitudinal Health Study Following the Firework-disaster in Enschede, The Netherlands
Very few longitudinal health studies after disasters published data on the determinants of loss to follow up. However, these determinants provide important information for future disaster studies to improve th...
