27 Result(s)

Article

Transplantation for myelofibrosis patients in the ruxolitinib era: a registry study from the Société Francophone de Greffe de Moelle et de Thérapie Cellulaire

In this SFGM-TC registry study, we report the results after stem cell transplantation (HSCT) in 305 myelofibrosis patients, in order to determine potential risk factors associated with outcomes, especially reg...

Sara Villar, Sylvie Chevret, Xavier Poire, Magalie Joris… in Bone Marrow Transplantation (2024)

Article

Durable engraftment after pharmacological pre-transplant immune suppression followed by reduced-toxicity myeloablative haploidentical stem cell transplantation in highly HLA-immunized adults with sickle cell disease

Allogeneic stem cell transplantation (Allo-SCT) is the only rapidly available curative treatment modality in patients with severe sickle cell disease (SCD). The development of reduced-toxicity myeloablative co...

Sabine Fürst, Emmanuelle Bernit, Faezeh Legrand… in Bone Marrow Transplantation (2024)

Article

Life-threatening toxicities upon Pembrolizumab intake: could pharmacokinetics be the bad guy?

We report the case of an adult patient diagnosed with Hodgkin’s lymphoma who was scheduled for Pembrolizumab after failure of standard therapy. After three well-tolerated courses of Pembrolizumab, a PET scan s...

Mourad Hamimed, Raynier Devillier… in Cancer Chemotherapy and Pharmacology (2024)

Article

Peripheral blood haploidentical hematopoietic cell transplantation for patients aged 70 years and over with acute myeloid leukemia or high-risk myelodysplastic syndrome

Haploidentical stem cell transplantation (Haplo-SCT) using non-myeloablative conditioning regimen (NMAC) has extended the feasibility of allogeneic transplantation, notably in older patients. However, there is...

Samia Harbi, Louison Brac de la Perriere… in Bone Marrow Transplantation (2024)

Article

Allogeneic hematopoietic stem cell transplantation for adults with therapy-related acute myeloid leukaemia: a retrospective multicentre study on behalf of the SFGM-TC

We report the results from a multicentre retrospective study of 220 adult patients who underwent allogeneic hematopoietic stem cell transplantation (alloHSCT) for therapy-related acute myeloid leukaemia (t-AML...

Gaëlle Rey, Elisabeth Daguenet, Paul Bonjean… in Bone Marrow Transplantation (2023)

Article

GVHD prophylaxis with post-transplant cyclophosphamide results in lower incidence of GVHD and allows faster immunosuppressive treatment reduction compared to antithymocyte globulin in 10/10 HLA-matched unrelated allogeneic hematopoietic cell transplantation

François Dachy, Sabine Furst, Boris Calmels… in Bone Marrow Transplantation (2023)

Article

Reduced post-transplant cyclophosphamide doses in haploidentical hematopoietic cell transplantation for elderly patients with hematological malignancies

Although post-transplant cyclophosphamide (PT-Cy) is effective for graft-versus-host disease (GVHD) prophylaxis, it is associated with toxicities, which might be dose-dependent. We compared the outcomes with P...

Rémy Duléry, Claire Goudet, Daniele Mannina… in Bone Marrow Transplantation (2023)

Article

Donor lymphocyte infusions after haploidentical stem cell transplantation with PTCY: A study on behalf of the EBMT cellular therapy & immunobiology working party

Donor lymphocyte infusion (DLI) is a treatment option to prevent or treat relapse after allogeneic hematopoietic cell transplantation (HCT). We here report data for 173 patients who received one or multiple DL...

Nicole Santoro, Jarl E. Mooyaart, Raynier Devillier… in Bone Marrow Transplantation (2023)

Article

Impact of second-degree related donor on the outcomes of T cell-replete haploidentical transplantation with post-transplant cyclophosphamide

Donor selection may contribute to improve clinical outcomes of T cell-replete haploidentical stem cell transplantation (Haplo-SCT) with post-transplant cyclophosphamide (PT-Cy). Impact of second-degree related...

Jacopo Mariotti, Anna Maria Raiola, Andrea Evangelista… in Bone Marrow Transplantation (2022)

Article

Reduced intensity versus non-myeloablative conditioning regimen for haploidentical transplantation and post-transplantation cyclophosphamide in complete remission acute myeloid leukemia: a study from the ALWP of the EBMT

The optimal conditioning regimen prior haploidentical stem cell transplantation (Haplo-SCT) with post transplantation cyclophosphamide (PT-Cy) for acute myeloid leukemia (AML) remains unknown. A non-myeloablat...

Raynier Devillier, Jacques-Emmanuel Galimard, Myriam Labopin… in Bone Marrow Transplantation (2022)

Article

Posttransplantation cyclophosphamide vs. antithymocyte globulin as GVHD prophylaxis for mismatched unrelated hematopoietic stem cell transplantation

Posttransplant cyclophosphamide (PT-Cy) is an efficient GVHD prophylaxis but has not been extensively evaluated in mismatched unrelated donor (MMUD) allo-HSCT, for which antithymocyte globulin (ATG) is still c...

Charlotte Nykolyszyn, Angela Granata, Thomas Pagliardini… in Bone Marrow Transplantation (2020)

Article

Peripheral blood stem cell for haploidentical transplantation with post-transplant high dose cyclophosphamide: detailed analysis of 181 consecutive patients

While bone marrow (BM) grafts were initially used for T-replete HLA-haploidentical related donors transplantation (Haplo-SCT) with post-transplantation cyclophosphamide (PT-Cy), the use of peripheral blood ste...

Angela Granata, Sabine Fürst, Stefania Bramanti… in Bone Marrow Transplantation (2019)

Article

The new refined minnesota risk score for acute graft-versus-host disease predicts overall survival and non-relapse mortality after T cell-replete haploidentical stem cell transplant with post-transplant cyclophosphamide

We propose to test whether the new refined Minnesota risk score, which represents a new tool for acute Graft-versus-Host-Disease (aGVHD) grading, may be useful to predict the final outcome of patients with aGV...

Jacopo Mariotti, Angela Granata, Stefania Bramanti… in Bone Marrow Transplantation (2019)

Article

Post-transplantation cyclophosphamide-based haploidentical versus Atg-based unrelated donor allogeneic stem cell transplantation for patients younger than 60 years with hematological malignancies: a single-center experience of 209 patients

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited by availability of HLA-matched sibling donors (MSDs). The alternative use of unrelated donors (UDs) is currently challenged by haploide...

Thomas Pagliardini, Samia Harbi, Sabine Fürst, Luca Castagna… in Bone Marrow Transplantation (2019)

Article

Immune signature drives leukemia escape and relapse after hematopoietic cell transplantation

Transplantation of hematopoietic cells from a healthy individual (allogeneic hematopoietic cell transplantation (allo-HCT)) demonstrates that adoptive immunotherapy can cure blood cancers: still, post-transpla...

Cristina Toffalori, Laura Zito, Valentina Gambacorta, Michela Riba… in Nature Medicine (2019)