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Open AccessSelective cleavage of ncRNA and antiviral activity by RNase2/EDN in THP1-induced macrophages
RNase2 is the member of the RNaseA family most abundant in macrophages. Here, we knocked out RNase2 in THP-1 cells and analysed the response to Respiratory Syncytial Virus (RSV). RSV induced RNase2 expression, wh...
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Article
Open AccessHuman RNase3 immune modulation by catalytic-dependent and independent modes in a macrophage-cell line infection model
The human RNase3 is a member of the RNaseA superfamily involved in host immunity. RNase3 is expressed by leukocytes and shows broad-spectrum antimicrobial activity. Together with a direct antimicrobial action,...
