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  1. Article

    Open Access

    Targeting the oncogenic protein beta-catenin to enhance chemotherapy outcome against solid human cancers

    Beta-catenin is a multifunctional oncogenic protein that contributes fundamentally to cell development and biology. Elevation in expression and activity of β-catenin has been implicated in many cancers and ass...

    Maher S Saifo, Donald R Rempinski Jr, Youcef M Rustum, Rami G Azrak in Molecular Cancer (2010)

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    Article

    The Chk1-Cdc25C regulation is involved in sensitizing A253 cells to a novel topoisomerase I inhibitor BNP1350 by bax gene transfer

    Promotion of apoptosis may potentiate the sensitivity of tumor cells to chemotherapeutic agents, thus improving the efficacy of cancer treatment. The transfection of the proapoptotic bax gene, which results in th...

    Ming-biao Yin, Gunnar Hapke, Bin Guo, Rami G Azrak, Cheryl Frank… in Oncogene (2001)