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Joint single-cell profiling resolves 5mC and 5hmC and reveals their distinct gene regulatory effects

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  1. Article

    Open Access

    Expanded palette of RNA base editors for comprehensive RBP-RNA interactome studies

    RNA binding proteins (RBPs) are key regulators of RNA processing and cellular function. Technologies to discover RNA targets of RBPs such as TRIBE (targets of RNA binding proteins identified by editing) and ST...

    Hugo C. Medina-Munoz, Eric Kofman, Pratibha Jagannatha… in Nature Communications (2024)

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  2. Article

    Open Access

    Modular affinity-labeling of the cytosine demethylation base elements in DNA

    5-methylcytosine is the most studied DNA epigenetic modification, having been linked to diverse biological processes and disease states. The elucidation of cytosine demethylation has drawn added attention the ...

    Fanny Wang, Osama K. Zahid, Uday Ghanty, Rahul M. Kohli, Adam R. Hall in Scientific Reports (2020)

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  3. Article

    Open Access

    High-performance CRISPR-Cas12a genome editing for combinatorial genetic screening

    CRISPR-based genetic screening has revolutionized cancer drug target discovery, yet reliable, multiplex gene editing to reveal synergies between gene targets remains a major challenge. Here, we present a simpl...

    Rodrigo A. Gier, Krista A. Budinich, Niklaus H. Evitt… in Nature Communications (2020)

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