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Article
Open AccessArtificial intelligence-enabled prediction of chemotherapy-induced cardiotoxicity from baseline electrocardiograms
Anthracyclines can cause cancer therapy-related cardiac dysfunction (CTRCD) that adversely affects prognosis. Despite guideline recommendations, only half of the patients undergo surveillance echocardiograms. ...
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Article
Open AccessPerturbational phenoty** of human blood cells reveals genetically determined latent traits associated with subsets of common diseases
Although genome-wide association studies (GWAS) have successfully linked genetic risk loci to various disorders, identifying underlying cellular biological mechanisms remains challenging due to the complex nat...
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Article
Open AccessA machine learning model for identifying patients at risk for wild-type transthyretin amyloid cardiomyopathy
Transthyretin amyloid cardiomyopathy, an often unrecognized cause of heart failure, is now treatable with a transthyretin stabilizer. It is therefore important to identify at-risk patients who can undergo targ...
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Article
Open AccessArtificial intelligence-enabled fully automated detection of cardiac amyloidosis using electrocardiograms and echocardiograms
Patients with rare conditions such as cardiac amyloidosis (CA) are difficult to identify, given the similarity of disease manifestations to more prevalent disorders. The deployment of approved therapies for CA...
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Article
The structure of a calsequestrin filament reveals mechanisms of familial arrhythmia
Mutations in the calcium-binding protein calsequestrin cause the highly lethal familial arrhythmia catecholaminergic polymorphic ventricular tachycardia (CPVT). In vivo, calsequestrin multimerizes into filamen...
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Article
Phenomap** for the Identification of Hypertensive Patients with the Myocardial Substrate for Heart Failure with Preserved Ejection Fraction
We sought to evaluate whether unbiased machine learning of dense phenotypic data (“phenomap**”) could identify distinct hypertension subgroups that are associated with the myocardial substrate (i.e., abnorma...
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Article
Open AccessPrioritizing causal disease genes using unbiased genomic features
Cardiovascular disease (CVD) is the leading cause of death in the developed world. Human genetic studies, including genome-wide sequencing and SNP-array approaches, promise to reveal disease genes and mechanis...
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Article
Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins
Combining analysis of host proteome and transcriptome perturbations induced by tumour virus proteins with ongoing genome-wide studies of cancer facilitates the prioritization of cancer genes.
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Article
Programming human pluripotent stem cells into white and brown adipocytes
The utility of human pluripotent stem cells is dependent on efficient differentiation protocols that convert these cells into relevant adult cell types. Here we report the robust and efficient differentiation ...
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Article
Identification of adult nephron progenitors capable of kidney regeneration in zebrafish
Fish can regenerate nephrons — the functional units of the kidney — following kidney injury, whereas adult mammals lack this ability. A previously unknown type of kidney cell responsible for this regeneration ...
