8 Result(s)

Article

A first-in-human phase I trial of daily oral zelenirstat, a N-myristoyltransferase inhibitor, in patients with advanced solid tumors and relapsed/refractory B-cell lymphomas

Myristoylation, the N-terminal addition of the fatty acid myristate to proteins, regulates membrane-bound signal transduction pathways important in cancer cell biology. This modification is catalyzed by two N-...

Randeep Sangha, Rahima Jamal, Jennifer Spratlin… in Investigational New Drugs (2024)

Article

Author Correction: Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Bertrand Routy, John G. Lenehan, Wilson H. Miller Jr, Rahima Jamal… in Nature Medicine (2024)

Article

Real-world analyses of therapy discontinuation of checkpoint inhibitors in metastatic melanoma patients

The ‘real-world’ patient population of metastatic melanoma is not fully represented in clinical trials investigating checkpoint inhibitors. We described therapy discontinuation in an unselected population-base...

Marina Amaral de Ávila Machado, Cristiano Soares de Moura… in Scientific Reports (2020)

Article

Phase I/II trial of Durvalumab plus Tremelimumab and stereotactic body radiotherapy for metastatic head and neck carcinoma

The efficacy of immunotherapy targeting the PD-1/PD-L1 pathway has previously been demonstrated in metastatic head and neck squamous cell carcinoma (HNSCC). Stereotactic Body Radiotherapy (SBRT) aims at ablati...

Houda Bahig, Francine Aubin, John Stagg, Olguta Gologan, Olivier Ballivy… in BMC Cancer (2019)

Article

Peripheral and local predictive immune signatures identified in a phase II trial of ipilimumab with carboplatin/paclitaxel in unresectable stage III or stage IV melanoma

Checkpoint blockade with ipilimumab provides long-term survival to a significant proportion of patients with metastatic melanoma. New approaches to increase survival and to predict which patients will benefit ...

Rahima Jamal, Réjean Lapointe, Eftihia Cocolakis… in Journal for ImmunoTherapy of Cancer (2017)

Article

Immune biomarker correlates from a Phase II study of ipilimumab (IPI) with carboplatin and paclitaxel (CP) in patients with unresectable stage III or IV metastatic melanoma (MM)

Réjean Lapointe, Rahima Jamal, Leon van Kempen… in Journal for ImmunoTherapy of Cancer (2015)

Article

Validity and reliability of bedside nursing assessments of pain, sedation and delirium

François Marquis, Rahima Jamal, Isabelle Ayotte… in Canadian Journal of Anesthesia (2006)