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Article
Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation
Unlike other nucleotide oligomerization domain-like receptors, Nlrp10 lacks a canonical leucine-rich repeat domain, suggesting that it is incapable of signal sensing and inflammasome formation. Here we show th...
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Article
Publisher Correction: Gut microbiota modulates weight gain in mice after discontinued smoke exposure
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Article
Gut microbiota modulates weight gain in mice after discontinued smoke exposure
Cigarette smoking constitutes a leading global cause of morbidity and preventable death1, and most active smokers report a desire or recent attempt to quit2. Smoking-cessation-induced weight gain (SCWG; 4.5 kg re...
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Article
Open AccessProbiotics impact the antibiotic resistance gene reservoir along the human GI tract in a person-specific and antibiotic-dependent manner
Antimicrobial resistance poses a substantial threat to human health. The gut microbiome is considered a reservoir for potential spread of resistance genes from commensals to pathogens, termed the gut resistome...
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Article
Open AccessImmunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia
Mechanisms driving the progression of chronic lymphocytic leukemia (CLL) from its early stages are not fully understood. The acquisition of molecular changes at the time of progression has been observed in a s...
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Article
Healthspan and lifespan extension by fecal microbiota transplantation into progeroid mice
The gut microbiome is emerging as a key regulator of several metabolic, immune and neuroendocrine pathways1,2. Gut microbiome deregulation has been implicated in major conditions such as obesity, type 2 diabetes,...
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Article
Open AccessGermline mutations in the spindle assembly checkpoint genes BUB1 and BUB3 are infrequent in familial colorectal cancer and polyposis
Germline mutations in BUB1 and BUB3 have been reported to increase the risk of develo** colorectal cancer (CRC) at young age, in presence of variegated aneuploidy and reminiscent dysmorphic traits of mosaic var...
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Article
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of t...
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Open AccessErratum: Scarce evidence of the causal role of germline mutations in UNC5C in hereditary colorectal cancer and polyposis
Scientific Reports 6: Article number: 20697; published online: 08 February 2016; updated: 20 April 2016. The original version of this Article contained errors in the spelling of the authors Elena Sánchez-Cuart...
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Open AccessScarce evidence of the causal role of germline mutations in UNC5C in hereditary colorectal cancer and polyposis
Germline mutations in UNC5C have been suggested to increase colorectal cancer (CRC) risk, thus causing hereditary CRC. However, the evidence gathered thus far is insufficient to include the study of the UNC5C gen...
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Article
Open AccessA comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing
As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full understanding of the variables affecting sequencing analysis output is required. Here using tumour-normal sample pairs from...
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Article
Non-coding recurrent mutations in chronic lymphocytic leukaemia
Chronic lymphocytic leukaemia (CLL) is a frequent disease in which the genetic alterations determining the clinicobiological behaviour are not fully understood. Here we describe a comprehensive evaluation of t...
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Article
Mutations in filamin C cause a new form of familial hypertrophic cardiomyopathy
Mutations in different genes encoding sarcomeric proteins are responsible for 50–60% of familial cases of hypertrophic cardiomyopathy (HCM); however, the genetic alterations causing the disease in one-third of...
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Article
Correction: Corrigendum: Signatures of mutational processes in human cancer
Nature 500, 415–421 (2013); doi:10.1038/nature12477 In the author list of this Article, the surname of Marcin Imielinski was misspelled as “Imielinsk”. This has been corrected in the HTML and PDF of the origin...
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Signatures of mutational processes in human cancer
All cancers are caused by somatic mutations; however, understanding of the biological processes generating these mutations is limited. The catalogue of somatic mutations from a cancer genome bears the signatur...
