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  1. No Access

    Article

    The cytotoxic action of four ammine/amine platinum(IV) dicarboxylates: a flow cytometric study

    We have used flow cytometry to study the mechanism of cytotoxic action of a series of ammine/amine Pt(IV) dicarboxylates [ammine diacetatodichloro(cyclohexylamine) platinum(IV), JM216; ammine dibutyratodichlor...

    MG Ormerod, RM Orr, CF O'Neill, T Chwalinski, JC Titley… in British Journal of Cancer (1996)

  2. No Access

    Article

    Evaluation of novel ammine/amine platinum (IV) dicarboxylates in L1210 murine leukaemia cells sensitive and resistant to cisplatin, tetraplatin or carboplatin

    Seventeen alkylamine ammine dicarboxylatodichloroplatinum(IV) complexes of general structure c,t,c-[PtCl2(OCOR1)2NH3(RNH2)], where R = aliphatic or alicyclic and R1 = aliphatic or aromatic, have been evaluated...

    RM Orr, CF O'Neill, MC Nicolson, CFJ Barnard, BA Murrer… in British Journal of Cancer (1994)

  3. No Access

    Article

    The role of apoptosis in cell killing by cisplatin: a flow cytometric study

    Cell killing of L1210 cells by cisplatin has been studied using flow cytometry and DNA gel electrophoresis. Ten hours after a supralethal dose of drug (100 microM), extensive apoptosis was induced. Cells were ...

    MG Ormerod, RM Orr, JH Peacock in British Journal of Cancer (1994)