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  1. No Access

    Article

    In vitro circumvention of cisplatin resistance by the novel sterically hindered platinum complex AMD473

    A novel sterically hindered platinum complex, AMD473 [cis-aminedichloro(2-methylpyridine) platinum (II)], has been selected for phase I clinical trials due to commence in 1997. AMD473 was rationally designed t...

    J Holford, SY Sharp, BA Murrer, M Abrams, LR Kelland in British Journal of Cancer (1998)

  2. No Access

    Article

    Evaluation of novel ammine/amine platinum (IV) dicarboxylates in L1210 murine leukaemia cells sensitive and resistant to cisplatin, tetraplatin or carboplatin

    Seventeen alkylamine ammine dicarboxylatodichloroplatinum(IV) complexes of general structure c,t,c-[PtCl2(OCOR1)2NH3(RNH2)], where R = aliphatic or alicyclic and R1 = aliphatic or aromatic, have been evaluated...

    RM Orr, CF O'Neill, MC Nicolson, CFJ Barnard, BA Murrer… in British Journal of Cancer (1994)

  3. No Access

    Article

    Lack of nephrotoxicity of oral ammine/amine platinum (IV) dicarboxylate complexes in rodents

    The comparative nephrotoxicity of i.v. cisplatin, i.v. carboplatin and six p.o. ammine/amine Pt(IV) dicarboxylates was studied in rodents following single MTD treatments. In mice, i.v. cisplatin caused protein...

    MJ McKeage, SE Morgan, FE Boxall, BA Murrer, GC Hard… in British Journal of Cancer (1993)