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Open AccessDisease control of acromegaly does not prevent excess mortality in the long term: results of a nationwide survey in Italy
This study aimed to assess the long-term outcome of patients with acromegaly.
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Sociodemographic profile, health-related behaviours and experiences of healthcare access in Italian transgender and gender diverse adult population
Information on the general health of transgender and gender diverse (TGD) individuals continues to be lacking. To bridge this gap, the National Institute of Health in Italy together with the National Office ag...
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Open AccessImprovement in clinical features of hypercortisolism during osilodrostat treatment: findings from the Phase III LINC 3 trial in Cushing's disease
Cushing’s disease is associated with substantial morbidity and impaired quality of life (QoL) resulting from excess cortisol exposure. The current study explored improvements in clinical signs and additional s...
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Open AccessLong-term pasireotide therapy in acromegaly: extensive real-life experience of a referral center
Pasireotide is a novel therapeutic option for patients with acromegaly resistant to first-generation somatostatin receptor ligands. To date, real-life data are still scant, therefore, the aim of the current st...
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Pasireotide effects on biochemical control and glycometabolic profile in acromegaly patients switched from combination therapies or unconventional dosages of somatostatin analogs
To evaluate the impact of pasireotide (PAS) therapy on hormonal and glycometabolic outcome in patients with acromegaly previously treated with combination medical therapies or unconventional dosages of first-g...
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Article
Open AccessCirculating myomiRNAs as biomarkers in patients with Cushing’s syndrome
Impairment of skeletal muscle mass and strength affects 40–70% of patients with active Cushing’s syndrome (CS). Glucocorticoid excess sustains muscle atrophy and weakness, while muscle-specific microRNAs (myom...
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Open AccessUnmet needs on the current medical management of Cushing’s syndrome: results from a Delphi panel of Italian endocrinologists
Cushing’s syndrome (CS) is a rare clinical condition caused by excessive cortisol secretion from adrenal glands. CS is associated with increased mortality and morbidity; therefore, a prompt diagnosis and an ef...
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The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction
Erectile dysfunction (ED) is one of the most prevalent male sexual dysfunctions. ED has been in the past mistakenly considered a purely psycho-sexological symptom by patients and doctors. However, an ever-grow...
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Open AccessControl of acromegaly in more than 90% of patients after 10 years of pegvisomant therapy: an European referral centre real-life experience
Pegvisomant (PEG) efficaciously controls IGF-I excess in acromegaly and possesses a positive impact on glucose metabolism. Data on very prolonged PEG treatment are still limited, therefore, we investigated the...
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Article
Open AccessSellar and parasellar lesions in the transition age: a retrospective Italian multi-centre study
Sellar/parasellar lesions have been studied in the adult and paediatric age range, but during the transition age their epidemiology, clinical manifestations, management and treatment outcomes have been poorly ...
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Article
Adult- and late-onset male hypogonadism: the clinical practice guidelines of the Italian Society of Andrology and Sexual Medicine (SIAMS) and the Italian Society of Endocrinology (SIE)
To provide the evidence-based recommendations on the role of testosterone (T) on age-related symptoms and signs remains.
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Article
Open AccessAndrological effects of SARS-Cov-2 infection: a systematic review and meta-analysis
The short- and long-term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarified. Our aim is to evaluate the available evidence regarding possible andrological consequences of COVID...
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Open AccessFirst baseline data of the Klinefelter ItaliaN Group (KING) cohort: clinical features of adult with Klinefelter syndrome in Italy
Klinefelter syndrome (KS) is frustratingly under-diagnosed. KS have a broad spectrum of clinical features, making it difficult to identify.
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Article
Open AccessAre there country-specific differences in the use of pegvisomant for acromegaly in clinical practice? An analysis from ACROSTUDY
A comprehensive picture of pegvisomant use for treating acromegaly in routine clinical practice in different countries is lacking. We aimed, therefore, to document country-specific behaviors in real-life pegvi...
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Article
Open AccessThe dopaminergic control of Cushing’s syndrome
Cushing’s Syndrome (CS), or chronic endogenous hypercortisolism, is a rare and serious disease due to corticotroph pituitary (Cushing’s disease, CD) and extra-pituitary (ectopic CS) tumours overproducing ACTH,...
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Article
Open AccessLong-term high-dose l-arginine supplementation in patients with vasculogenic erectile dysfunction: a multicentre, double-blind, randomized, placebo-controlled clinical trial
The current randomized, double-blind, placebo-controlled clinical trial addressed the effects on penile erectile function of relatively high daily oral doses (6 g/day) of l-ARG for 3 months (N = 51) compared to p...
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Article
Testosterone supplementation and bone parameters: a systematic review and meta-analysis study
The role of testosterone (T) replacement therapy (TRT) in subjects with late onset hypogonadism is still the object of an intense debate.
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Article
Open AccessMetabolic syndrome in the era of COVID-19 outbreak: impact of lockdown on cardiometabolic health
COVID-19 pandemics and cardiometabolic health are mutually interconnected. Chronic metabolic diseases are known risk factors for increased mortality after SARS-CoV-2 infection. In turn, COVID pandemics imposed...
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Remission in Cushing’s disease is predicted by cortisol burden and its withdrawal following pituitary surgery
To ascertain the predictors of remission and relapse in patients of Cushing’s disease (CD) undergoing pituitary transsphenoidal surgery (TSS).
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Article
Testosterone treatment in male patients with Klinefelter syndrome: a systematic review and meta-analysis
Low testosterone (T) in Klinefelter’s syndrome (KS) can contribute to typical features of the syndrome such as reduced bone mineral density, obesity, metabolic disturbances and increased cardiovascular risk. T...
