35 Result(s)

Article

Adherence to COPD management guidelines in general practice? A review of the literature

Chronic obstructive pulmonary disease (COPD) is a progressive illness that is mostly managed in the general practice setting. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines are th...

J. Sehl, J. O’Doherty, R. O’Connor… in Irish Journal of Medical Science (1971 -) (2018)

Article

Youth mental health in deprived urban areas: a Delphi study on the role of the GP in early intervention

GPs, as healthcare professionals with whom young people commonly interact, have a central role in early intervention for mental health problems. However, successfully fulfilling this role is a challenge, and t...

E. Schaffalitzky, D. Leahy, W. Cullen… in Irish Journal of Medical Science (1971 -) (2015)

Article

Timing of complementary food introduction and age at diagnosis of type 1 diabetes: the SEARCH nutrition ancillary study (SNAS)

The association between timing of complementary food introduction and age at diagnosis of type 1 diabetes was investigated among 1077 children in the SEARCH for Diabetes in Youth study. Age at diagnosis was 5 ...

T L Crume, J Crandell, J M Norris, D Dabelea… in European Journal of Clinical Nutrition (2014)

Article

HRG-1 enhances cancer cell invasive potential and couples glucose metabolism to cytosolic/extracellular pH gradient regulation by the vacuolar-H⁺ ATPase

Haeme-responsive gene (HRG)-1 encodes a 16-kDa transmembrane protein that is induced by insulin-like growth factor-1 (IGF-1) and associates with the vacuolar-(H⁺) ATPase (V-ATPase). We previously reported that HR...

F M Fogarty, J O'Keeffe, A Zhadanov, D Papkovsky, V Ayllon, R O'Connor in Oncogene (2014)

Article

PDLIM2 expression is driven by vitamin D and is involved in the pro-adhesion, and anti-migration and -invasion activity of vitamin D

1Alpha,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃], the biologically active form of vitamin D_3, is a pleiotropic hormone that exerts its effects on a wide range of tissues, resulting in different biological responses su...

E Vanoirbeek, G Eelen, L Verlinden, G Carmeliet, C Mathieu, R Bouillon… in Oncogene (2014)

Article

An evidence-based assessment of primary care needs in an economically deprived Urban community

As healthcare and longevity improve and fertility rates decline, we see a demographic shift towards a predominantly elderly population. Because ageing brings its own physiological changes and complications, th...

C. Power, R. O’Connor, S. Dunne, P. Finucane, W. Cullen… in Irish Journal of Medical Science (2013)

Article

A study of needle stick injuries among non-consultant hospital doctors in Ireland

NCHDs are exposed to a great number of blood-borne infections. Needle stick injuries are possibly the main route of acquiring such infections from a non-consultant hospital doctors (NCHDs) perspective. This st...

M. B. O’Connor, M. J. Hannon, D. Cagney, U. Harrington… in Irish Journal of Medical Science (2011)

Article

Tyrosine kinase inhibitors potentiate the cytotoxicity of MDR-substrate anticancer agents independent of growth factor receptor status in lung cancer cell lines

To investigate the interactions of Epidermal Growth Factor Receptor (EGFR)-inhibiting tyrosine kinase inhibitors (TKIs) on P-gp-mediated drug resistance, we tested three TKIs, lapatinib, gefitinib and erlotini...

D. M. Collins, J. Crown, N. O’Donovan, A. Devery… in Investigational New Drugs (2010)

Article

Mitochondrial pyrimidine nucleotide carrier (PNC1) regulates mitochondrial biogenesis and the invasive phenotype of cancer cells

The insulin-like growth factor (IGF-I) signalling pathway is essential for metabolism, cell growth and survival. It induces expression of the mitochondrial pyrimidine nucleotide carrier 1 (PNC1) in transformed...

C Favre, A Zhdanov, M Leahy, D Papkovsky, R O'Connor in Oncogene (2010)

Article

Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels

The lysosomal cysteine proteinase cathepsin L is involved in proteolytic processing of internalized proteins. In transformed cells, where it is frequently overexpressed, its intracellular localization and func...

R Navab, C Pedraza, L Fallavollita, N Wang, E Chevet, P Auguste, S Jenna, Z You… in Oncogene (2008)

Article

PBK/TOPK promotes tumour cell proliferation through p38 MAPK activity and regulation of the DNA damage response

The contribution of the insulin-like growth-factor-I receptor (IGF-IR) to tumour progression is well documented. To identify new mediators of IGF-IR function in cancer, we recently isolated genes differentiall...

V Ayllón, R O'Connor in Oncogene (2007)

Article

A phase I clinical and pharmacokinetic study of the multi-drug resistance protein-1 (MRP-1) inhibitor sulindac, in combination with epirubicin in patients with advanced cancer

Purpose: Multi-drug resistance mediated by ATP-binding cassette trans-membrane protein pumps is an important cause of cancer treatment failure. Sulindac has been shown to be a competitive...

R. O’Connor, M. O’Leary, J. Ballot, C. D. Collins… in Cancer Chemotherapy and Pharmacology (2007)

Article

An ominous inguinal hernia

HM McMillan, R Salman, MF Khan, O McAnena, R O’Connor in Irish Journal of Medical Science (2004)