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Chapter
Transfer of Maternal Leukocytes to the Infant by Human Milk
Human milk contains a complex immune system that consists not only of a host of soluble direct-acting antimicrobial agents (GOLDMAN and SMITH 1973), anti-in-flammatory factors (GOLDMAN et al. 1986), and immunomod...
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Article
RESPIRATORY SYNCYTIAL VIRUS (RSV) ENHANCES THE EXPRESSION OF ANTIGEN PRESENTING MOLECULES, ACCESSORY LIGANDS AND POLYMERIC IMMUNOGLOBULIN RECEPTOR BY UPPER AIRWAY EPITHELIUM. • 48
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Article
Substrate inhibition of adenosine phosphorylation in adenosine deaminase deficiency and adenosine-mediated inhibition of PP-ribose-P dependent nucleotide synthesis in hypoxanthine phosphoribosyltransferase deficient erythrocytes
The metabolism of adenosine and its effects on phosphoribosylpyrophosphate, PP-ribose-P, dependent nucleotide synthesis were studied using erythrocytes from patients with adenosine deaminase and hypoxanthine p...
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Chapter
The Effect of Feeding Human Milk on the Development of Immunity in Low Birth Weight Infants
Epidemiologic evidence suggests that infants fed cow’s milk rather than maternal milk have a higher frequency and severity of infectious, allergic, and possibly other inflammatory diseases of the gastrointesti...
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Article
923 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY, NEUTROPHIL DYSFUNCTION AND CHROMOBACTERIUM VIOLACEUM SEPSIS
A three year old white male with Class I glucose-6-phosphate dehydrogenase (G-6-PD) deficiency developed fever and lethargy. In spite of antibiotics, he developed septic shock and died twelve hours later. Bloo...
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Article
PERSISTENCE OF IMMUNOLOGIC FACTORS FROM HUMAN MILK IN THE INTESTINAL TRACT OF VERY LOW BIRTH WEIGHT INFANTS
The use of banked human milk for premature infants is frequently based on the potential importance of its immunologic components. We therefore examined the persistence of some immunologic factors from human mi...
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Article
STRUCTURAL BASIS FOR THE MULTIPLE FUNCTIONS OF SECRETORY COMPONENT
Secretory component (SC) plays a central role in the mucosal immune system. This polypeptide serves as the epithelial cell receptor and transporter for polymeric IgA (pIgA) and protects IgA from proteolysis. T...
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Article
RAPID DEVELOPMENT OF INFANTS POLYMERIC IgA IN THE SERUM OF INFANTS
Three molecular forms of IgA, monomeric (mIgA), polymeric (pIgA), and secretory (sIgA) make up approximately 85,15, and 1% of the IgA in adult serum. IgA concentration in secretions (sIgA) increases with age m...
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Article
699 QUANTITATIVE MICROIMMUNOASSAY FOR IMMUNO-GLOBULIN CLASS SPECIFIC HUMAN ANTIBODIES
In order to evaluate antibody responses in immunodeficient patients, we have developed a modification of the enzyme linked immunosorbent assay (ELISA) which is 1) sensitive, 2) specific for immunoglobulin clas...
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Article
LYMPHOCYTE MOTILITY IN CHRONIC LYMPHOCYTIC LEUKEMIA(CLL)AND X-UNKED HYPO-M-GLOBULINEMIA
We have found that circulating human T lymphocytes are motile, whereas unstimulated B lymphocytes are not (RES, J.Reticuloendothel.Soc.20:331, 1976). Since motility is a functional morphologic marker of normal...
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Article
EFFECT OF RBC TRANSFUSIONS ON ADENOSINE DEAMINASE(ADA) DEFICIENT SEVERE COMBINED IMMUNODEFICIENCY(SCID)
Previous work suggests that the immunological defect in ADA deficient SCID is mediated by increased lymphocyte nucleotides including ATP and cAMP. We attempted to improve this tmmunological deficit in a 10-mon...
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Article
QUANTITATIVE IMMUNOSORBE NT ASSAY FOR SlgA
Studies of the secretory immune system have been hampered by the lack of an assay to specifically measure SIgA in secretions which also contain serum IgA and free secretory componet (FSC). We have developed an...