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Chapter
Concentrations of Interleukin-10 in Preterm Milk
Despite the protective effects of human milk against necrotizing enterocolitis (NEC), the incidence of NEC is highest in the extremely low birthweight (ELBW) infant, and only minimally decreased with the feedi...
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Chapter
Transfer of Maternal Leukocytes to the Infant by Human Milk
Human milk contains a complex immune system that consists not only of a host of soluble direct-acting antimicrobial agents (GOLDMAN and SMITH 1973), anti-in-flammatory factors (GOLDMAN et al. 1986), and immunomod...
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Chapter
Prostaglandin Metabolism
Prostaglandins are 20-carbon polyunsaturated fatty acids containing a cyclopentane ring and two side chains, and they are distinguished by their very potent biological activities. The basic skeleton, prostanoi...
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Article
Arachidonic acid and male genital differentiation
Arachidonic acid (AA) prevents neural tube defects, cleft palate, and micrognathia in the rat models of diabetic embryopathy and neural tube defects in the mouse embryo culture model. In this study, the involv...
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Chapter
Report of Epidemiology Workshop: Recommendations Regarding Future Research Concerning the Effects of Human Milk Upon Infant Recipients
Investigations on the potential mechanisms of protection offered by breast feeding against infections and other diseases are sufficiently advanced to raise many questions concerning the in vivo advantages of bank...
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Chapter and Conference Paper
Photochemical Generation of Nineteen-Electron Organometallic Complexes and their Use as Reducing Agents in Micellar Systems
We have discovered a new class of organometallic complexes that are very powerful reducing agents. In some cases these reducing agents have oxidation potentials up to ≈ 2 volts (vs NHE). In addition to being q...
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Chapter
The Effect of Feeding Human Milk on the Development of Immunity in Low Birth Weight Infants
Epidemiologic evidence suggests that infants fed cow’s milk rather than maternal milk have a higher frequency and severity of infectious, allergic, and possibly other inflammatory diseases of the gastrointesti...
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Chapter
Report of Epodemiology Workshop: Introduction
As a result of a growing body of knowledge about variations in the volume and composition of human milk, many questions have arisen concerning the determinants of lactational performance, the effects of human ...
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Article
PERSISTENCE OF IMMUNOLOGIC FACTORS FROM HUMAN MILK IN THE INTESTINAL TRACT OF VERY LOW BIRTH WEIGHT INFANTS
The use of banked human milk for premature infants is frequently based on the potential importance of its immunologic components. We therefore examined the persistence of some immunologic factors from human mi...
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Article
Evidence for involvement of arachidonic acid in the teratogenic action of glucocorticoids
In addition to inhibiting shelf elevation glucocorticoids have been shown by us to inhibit breakdown of the medial edge epithelium of fetal palatal shelves from steroid-sensitive mouse strains in vivo and in a...
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Article
Biochemical mechanism of corticoid-induced cleft palate in rats linked to anti-inflammatory action
Glucocorticoids produce cleft palate in offspring of rodents in direct relation to their anti-inflammatory potency. Recently,the anti-inflammatory action of glucocorticoids has been shown to be inhibition of a...
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Article
LYMPHOCYTE MOTILITY IN CHRONIC LYMPHOCYTIC LEUKEMIA(CLL)AND X-UNKED HYPO-M-GLOBULINEMIA
We have found that circulating human T lymphocytes are motile, whereas unstimulated B lymphocytes are not (RES, J.Reticuloendothel.Soc.20:331, 1976). Since motility is a functional morphologic marker of normal...
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Article
EFFECT OF RBC TRANSFUSIONS ON ADENOSINE DEAMINASE(ADA) DEFICIENT SEVERE COMBINED IMMUNODEFICIENCY(SCID)
Previous work suggests that the immunological defect in ADA deficient SCID is mediated by increased lymphocyte nucleotides including ATP and cAMP. We attempted to improve this tmmunological deficit in a 10-mon...
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Article
QUANTITATIVE IMMUNOSORBE NT ASSAY FOR SlgA
Studies of the secretory immune system have been hampered by the lack of an assay to specifically measure SIgA in secretions which also contain serum IgA and free secretory componet (FSC). We have developed an...
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Article
Is feminine differentiation of the brain hormonally determined?
The androgen insensitive, genetically male rat pseudohermaphrodite displays neither masculine or feminine sexual behavior when primed with the appropriate sex hormones. although in the absence of androgen impr...
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Chapter
Recent Studies on the Intersexual Programming of the Genetic Rat Male Pseudohermaphrodite
During the last few years our development of highly specific and potent inhibitors of testosterone and corticosterone biosynthetic enzymes and more recently, our introduction of the use of antibodies to testos...
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Article
The Cells of Human Colostrum II. Synthesis of IgA and β1c
Extract: The production of IgG, IgA, IgM, β1c, and the secretory piece (SP) by the cells of human colostrum was investigated by radioimmunoelectrophoresis. The synthesis of IgA and β1c by the cells was demonst...
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Article
The Cells of Human Colostrum. I. In Vitro Studies of Morphology and Functions
Extract: The morphology and certain functions of human colostral cells were studied in vitro. Colostrum from 60 human females contained neutrophils, small lymphocytes, macrophages and occasional epithelial cells....