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Article
Survey on paediatric tumour boards in Europe: current situation and results from the ExPo-r-Net project
Under the ExPO-r-NeT project (European Expert Paediatric Oncology Reference Network for Diagnostics and Treatment), we aimed to identify paediatric oncology tumour boards in Europe to investigate the kind of t...
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Article
Open Access123I-mIBG scintigraphy in neuroblastoma: development of a SIOPEN semi-quantitative reporting ,method by an international panel
A robust method is required to standardise objective reporting of diagnostic 123I-mIBG images in neuroblastoma. Prerequisites for an appropriate system are low inter- and intra-observer error and reproducibility ...
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Article
Open AccessSegmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study)
In neuroblastoma (NB), the presence of segmental chromosome alterations (SCAs) is associated with a higher risk of relapse.
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Article
Open AccessCriteria for evaluation of disease extent by 123I-metaiodobenzylguanidine scans in neuroblastoma: a report for the International Neuroblastoma Risk Group (INRG) Task Force
Neuroblastoma is an embryonic tumour of the sympathetic nervous system, metastatic in half of the patients at diagnosis, with a high preponderance of osteomedullary disease, making accurate evaluation of metas...
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Article
Medium- and short-chain dehydrogenase/reductase gene and protein families
The structure-function relationships of alcohol dehydrogenases from the large family of short-chain dehydrogenase/reductase (SDR) enzymes are described. It seems that while mammals evolved with a medium-chain ...
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Article
Open AccessTreatment of localised resectable neuroblastoma. Results of the LNESG1 study by the SIOP Europe Neuroblastoma Group
Main objective of this study was to confirm that surgery alone is an effective and safe treatment for localised resectable neuroblastoma except stage 2 with amplified MYCN gene (MYCNA). Of 427 eligible stages 1–2...
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Article
28 years of high-dose therapy and SCT for neuroblastoma in Europe: lessons from more than 4000 procedures
Between 1978 and 2006, the European Group for Blood and Marrow Transplantation registered 4098 high-dose therapy (HDT) procedures followed by stem cell rescue (SCR) (3974 autologous/124 allogeneic) in patients...
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Article
Open AccessSalvage high-dose chemotherapy for children with extragonadal germ-cell tumours
We reviewed the European Group for Blood and Marrow Transplantation (EBMT) experience with salvage high-dose chemotherapy (HDC) in paediatric patients with extragonadal germ-cell tumour (GCT). A total of 23 ch...
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Article
Evolving role of myeloablative chemotherapy in the treatment of childhood brain tumours
Primary brain tumours, a heterogeneous group of cancer that constitute the second most common cancer in childhood, were historically treated with neurosurgical resection and radiation therapy. Chemotherapy has...
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Chapter and Conference Paper
High Dose Chemotherapy in High-Risk Ewing Tumours: Results in 156 (El)CESS Patients
Primary metastases and relapse in Ewing tumours represent adverse risk factors leading to a poor prognosis for event free survival (EFS). Whereas patients with localised Ewing tumours have an EFS probability o...
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Article
Unequivocal identification of disseminated tumor cells in the bone marrow by combining immunological and genetic approaches – functional and prognastic information
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Article
Low incidence of molecular evidence for tumour in PBPC harvests from patients with high risk Ewing tumours
Reverse transcriptase polymerase chain reaction (RT-PCR) was applied to evaluate the frequency of tumour cells in PBPC products from 15 high risk Ewing tumour (ET) patients who were treated according to EICESS...
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Article
Organ toxicity and quality of life after allogeneic bone marrow transplantation in pediatric patients: a single centre retrospective analysis
One hundred and fifty five pediatric patients underwent allogeneic bone marrow transplantation between 1980 and 1996 in the St Anna Children’s Hospital in Vienna with an overall survival of 52.3% (81 patients)...
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Chapter
Genetic Heterogeneity in Ewing Tumors and Neuroblastomas
The aim of this study was to investigate genetic changes occurring in Ewing Tumors (ETs) and Neuroblastomas (NBs). We analyzed whether the same genetic alteration, i.e. the deletion of genetic material at chro...
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Chapter
Malignome im Kindesalter
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Article
Transplantation activities and treatment strategies in paediatric stem cell transplantation centres: a report from the EBMT Working Party on Paediatric Diseases
To determine the current approach to stem cell transplantation (SCT) in centres which treat predominantly paediatric patients, a questionnaire was sent to 67 centres known by the EBMT registry to perform SCT m...
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Article
Resolution of early cytomegalovirus (CMV) infection after leukocyte transfusion therapy from a CMV seropositive donor
A 2 year and 8 month old CMV-negative boy suffering from stage III neuroblastoma underwent ABMT in first very good partial remission. He acquired early CMV infection on day +5, followed by consecutive graft fa...
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Article
Double megatherapy and autologous bone marrow transplantation for advanced neuroblastoma: the LMCE2 study
In the LMCE1 study using a single course of megatherapy most of the relapses occurred during the first 2 years after autologous bone marrow transplantation. A second pilot study (LMCE2) was therefore set up us...
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Chapter
State of X-Ray Structure Determination of Ascorbate Oxidase from Green Zucchini Squash
The copper enzyme ascorbate oxidase ( E.C. 1.10.3.3 ) belongs to the group of “blue oxidases”. According to recent investigations of Avigliano et al.(1983) the enzyme has a molecular weight of 145,000 with a c...
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Chapter and Conference Paper
The Structure of the Selenoenzyme GSH Peroxidase
The tetrameric selenoenzyme GSH peroxidase (M=84000) catalyzes the reduction of a variety of hydroperoxides including H2O2 and serves to protect biomembranes and other essential cellular components against oxidat...