![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
-
Article
HYPERANDROGENISM AS A CAUSE OF EARLY POLYCYSTIC OVARY SYNDROME (PCOS) IN GIRLS WITH CENTRAL PRECOCIOUS PUBERTY (CPP)
Increased adrenal androgens are often observed in girls with CPP. The hyperandrogenism is not affected by the therapy with GnRh analog (GnRHA). We performed an i.v. ACTH stimulation test (0.25mg) in 42 girls w...
-
Article
135 PUBERTAL DEVELOPMENT AND FINAL HEIGHT IN CIRLS WITH CENTRAL PRECOCIOUS PUBERTY (CPP) AFTER THERAPY WITH THE Gn-RII ANALOC D-TRP-6-LII-RII
Fifteen girls with CPP who have been treated with D-TRP-6-LH-RII (13 daily s.c.; 2 monthly i.m.) for 1 to 5 yrs were followed after therapy for 6 months to 4 yrs. Resumption of pubertal developmont was evident...
-
Article
GROWTH HORMONE (GH) IS NORMAL IN GIRLS WITH PRECOCIOUS PUBERTY DURING SUPPRESSIVE THERAPY WITH LH-RH ANALOGUE (D-TRP-6-LH-RH)
The inhibition of gonadotropin secretion in children with central precocious puberty treated with LH-RH analogues results in suppression of the pubertal development, including growth velocity. In some patients...
-
Article
190 LONG TERM THERAPY OF PRECOCIOUS PUBERTY WITH THE SUPERACTIVE LH-RH ANALOGUE D-TRP-6-LH-RH
Five girls and one boy with precocious puberty have been treated for 2-4 yrs with D-TRP-6-LH-RH (0.45-1.5 mcg/kg/day s.c.). LH and FSH secretion assessed by LRH tests remained suppressed in 4 patients; in 2 “e...
-
Article
Delayed puberty and hypoplastic uterus associated with hyperprolactinemia and successfully treated with bromocriptine
A 15 year-old-girl referred because of primary amenorrhea was found to have a hypoplastic uterus and persistent hyperprolactinemia (72-110 ng/ml). Pubertal development was retarded: breasts Tanner stage 3, pub...
-
Article
Comparison of estrogen induced breast development in girls with hyper- or hypo-gonadotrophic hypogonadism
Breast growth induced by estrogen (and progesteron) administered for 0.5-4 yrs, was evaluated in girls aged 11-22 yrs belonging to 4 clinical entities.
-
Article
Parathyroid (PTH) infusion test in hypo- (HP), pseudoshypo- (PHP) and pseudopseudohypoparathyroidism (PPHP)
Ten healthy children, 3 children with HP, a child with PHP and a child with PPHP were infused with 250 U PTH over 15 min. The renal excretion of cyclic AMP, P, Ca, HCO3, Na and K was measured and compared to 28 a...
-
Article
Kallman's syndrom with high set osmotic threshold (OT) and deficient thirst
A patient with Kallman's syndrom is presented, who had deficient thirst mechanism and high set OT for vasopressin secretion. Random determinations of plasma osmolality (Posm) revealed high values of 296-307 mO...
-
Article
Instable osmoreceptors and deficient thirst in hypothalamic hypopituitarism
A unique abnormality of osmoreceptors is reported in a child with hypothalamic hypopituitarism. Anterior pituitary testing revealed deficiency of GH, TSH and ACTH. The clinical course was characterized by fluc...
-
Article
Endcrine studies in anorexia nervosa (AN) concurrent with XO gonadal dysgenesis (GD)
Comprehensive endocrinological investigations were performed in a 15 yr old girl with XO-GD during AN and after recovery. This is the 10th report and first endocrine study of this combination. Basal parameters...
-
Article
Prolactin deficiency, obesity and enlarged testes - a new syndrome?
An infant with progressive obesity and bulimia present from birth was first seen by us at the age of 1 year and has now been followed for 3 years. He grew consistently along the 90th percentile with slight bon...
-
Article
LH AND FSH RESPONSE TO LH-RH IN 27 GIRLS WITH PRECOCIOUS PUBERTY
An LH-RH test was done in 27 girls with precocious puberty (PP), 26 idiopathic and one with a brain tumor, and in 47 girls with normal puberty (pubertal staging according to Tanner). In 10 girls with PP tested...
-
Article
THE ADVANTAGE OF INTERMITTENT HGH THERAPY IN PATIENTS WITH ISOLATED AND COMBINED HGH DEFICIENCY
Out of 46 patients treated by an intermittent HGH regime, 5 pts. with isol. HGH deficiency (IGHD) and 5 pts. with panhypopituitarism (CGHD) are presented. HGH was administered thrice weekly, 1–3 mg/injection, ...