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177 Result(s)
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Article
The Atropomer Composition of Iopromide as an Indicator for Assessment of the Quality of its Substance and Medincal Formulations
The atropisomer composition of iopromide substance and formulations is discussed. At 120 °C in aqueous iopromide solution, its atropisomers were found to be converted to conformers, which reached equilibrium w...
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Article
Experience in creating new drugs using traditional technologies
Working hypotheses for the creation of new potential drugs including Class III antiarrhythmic (nibentan, niferidyl), antiallergic (theoritin), and antituberculosis (hixozid) agents are formulated and experimen...
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Article
A potential combined formulation containing vinpocetin and succinic acid
Succinic acid bas been found to be able to potentiate the antihypoxic activity of vinpocetin. This property (potentiation) provided grounds for creating a new combined formulation containing vinpocetin and suc...
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Article
New potential antihypoxants based on 2-ethyl-3-(N,N-dimethylcarbamoyloxy)-6-methylpyridine
It is established that succinic acid is capable of potentiating (synergism) the antihypoxic activity of 3-hydroxypyridine derivatives such as the succinate (Ia) and hydrochloride (Ib) of 3-(N,N-dimethylcarbamoylo...
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Article
New group of class III antiarrhythmic drugs: piperid-4-ylethane derivatives
A series of new piperid-4-ylethane derivatives possessing antiarrhythmic activity has been synthesized and studied. The most active compound, 1-(4-fluorophenyl)-1-(4-nitrobenzoylamino)-2-(N-ethylpiperid-4-yl)etha...
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Article
A new group of 1-and 7-[ω-(benzhydryl-1-alkyl]-3methylxanthine derivatives with antihistamine activity
Directed synthesis using the accessible compound 3-methylxanthine was used to obtain a new group of 1-and 7-[ω-(benzhydryl-1)alkyl]-3-methylxanthine derivatives which functioned as histamine receptor blockers....
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Article
Synthesis and Pharmacological Activity of N-Arylamidine Derivatives
A series of eleven N-arylamidine derivatives were synthesized and tested for anti-inflammatory, analgesic, and antipyretic properties. In these respects, the synthesized compounds exhibit no advantages over th...
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Article
Combined Action of the Anticholinesterase Drug Aminostigmine and the Antidepressant Pyrazidole on Mnemonic Function in Rats and Mice
The effect of aminostigmine alone and in combination with pyrazidole on mnemonic function in rats and mice was studied using passive avoidance conditioned reflex. Aminostigmine is comparable with the reference...
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Article
Drugs for chemotherapy and prophylaxis of influenza: Mechanisms, efficacy, and safety (a review)
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Article
Synthesis and Antituberculous Activity in vitro of Amidine and Hydrazidine Analogs of Pyrazinamide and Isoniazid
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Article
Spike Activity of Neurons in the Lateral Hypothalamus in Rats During Microiontophoretic Application of Melatonin and Noradrenaline
Microiontophoretic application of melatonin to the perineuronal space of nerve cells in the lateral hypothalamus of WAG and Fischer-344 rats led to decreases in the frequency and regularization of the spike ac...
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Article
Modern Drugs for Treating Dermatomycosis
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Article
Drugs for the Treatment of Alzheimer's Disease
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Article
Experimental investigation of the neurochemical mechanism of action of the new gabaergic drug digam
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Article
The original domestic drug oxolin: Refined structure of the drug and summarized experience of oxolin ointment use in medicine
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Article
Structure—Function relationships in a series of 4-quinolone-3-carboxylic acid derivatives
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Article
Mechanisms of the antibacterial activity of fluoroquinolones and nitroquinolones with respect toEscherichia coli K12
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Article
Arbidol: A new domestic immunomodulant (A review)
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Article
Arbidol kinetics and effect upon influenza type a virus reproduction in MDCK cell culture
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Synthesis and antibacterial activity of furyl-substituted quinolonecarboxylic acids