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Article
Open AccessTargeting IL-11R/EZH2 signaling axis as a therapeutic strategy for osteosarcoma lung metastases
Lung metastases are the primary cause of death for osteosarcoma (OS) patients. We recently validated interleukin-11 receptor α (IL-11Rα) as a molecular target for the inhibition of OS lung metastases. Since th...
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Article
Open AccessInhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in NOTCH1 that facilitate glutamine oxidation. Here we identify oxidative phosphorylation (OxPhos) as a critical pathway for ...
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Article
Open AccessTargeting the NOTCH1-MYC-CD44 axis in leukemia-initiating cells in T-ALL
The NOTCH1-MYC-CD44 axis integrates cell-intrinsic and extrinsic signaling to ensure the persistence of leukemia-initiating cells (LICs) in T-cell acute lymphoblastic leukemia (T-ALL) but a common pathway to t...
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Article
Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML
Eukaryotic initiation factor 4A (eIF4A), the enzymatic core of the eIF4F complex essential for translation initiation, plays a key role in the oncogenic reprogramming of protein synthesis, and thus is a putati...
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Article
Characteristics of anti-CD19 CAR T cell infusion products associated with efficacy and toxicity in patients with large B cell lymphomas
Autologous chimeric antigen receptor (CAR) T cell therapies targeting CD19 have high efficacy in large B cell lymphomas (LBCLs), but long-term remissions are observed in less than half of patients, and treatme...
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Article
Open AccessAuthor Correction: FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation
The original version of this Article contained errors in the author affiliations. Qingnan Zhao, Xueqing **a, Longfei Huo and Shulin Li were incorrectly associated with Bei**g Institute for Brain Disorders, 10...
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Article
Open AccessFGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation
Few studies implicate immunoregulatory gene expression in tumor cells in arbitrating brain tumor progression. Here we show that fibrinogen-like protein 2 (FGL2) is highly expressed in glioma stem cells and pri...
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Article
Protein targeting chimeric molecules specific for bromodomain and extra-terminal motif family proteins are active against pre-clinical models of multiple myeloma
Bromodomain and extraterminal (BET) domain containing protein (BRD)-4 modulates the expression of oncogenes such as c-myc, and is a promising therapeutic target in diverse cancer types. We performed pre-clinical ...
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Article
Open AccessHSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes
T-cell-based immunotherapies are promising treatments for cancer patients. Although durable responses can be achieved in some patients, many patients fail to respond to these therapies, underscoring the need f...
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Article
Open AccessPredictive immune biomarker signatures in the tumor microenvironment of melanoma metastases associated with tumor-infiltrating lymphocyte (TIL) therapy
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Article
Open AccessAdoptive T-cell therapy improves treatment of canine non–Hodgkin lymphoma post chemotherapy
Clinical observations reveal that an augmented pace of T-cell recovery after chemotherapy correlates with improved tumor-free survival, suggesting the add-back of T cells after chemotherapy may improve outcome...
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Article
Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma
A link between B-cell-receptor (BCR) signalling and human B-cell lymphomas has been inferred from the study of immunoglobulin genes in human lymphomas and from work on mouse models, but more evidence is requir...
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Article
Casein kinase 1α governs antigen-receptor-induced NF-κB activation and human lymphoma cell survival
The CBM protein complex, consisting of the scaffold protein CARMA1, the adaptor protein BCL10 and the paracaspase enzyme MALT1, has a key role in transducing signals from the antigen receptors in T and B cells...
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Article
A loss-of-function RNA interference screen for molecular targets in cancer
Two papers this week highlight the impact of RNAi (RNA interference) in clinical medicine. Ngo et al. have developed a novel ‘Achilles heel' screen to identify genes that, if silenced, cause cancer cells to stop ...
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Article
The human B-cell lymphoma cell line RC-K8 has multiple genetic alterations that dysregulate the Rel/NF-κB signal transduction pathway
The human large B-cell lymphoma cell line RC-K8 has a rearranged REL locus that directs the production of a chimeric protein, termed REL-NRG (Non-Rel Gene). In this study, we show that RC-K8 cells have constituti...
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Article
Genomic-scale measurement of mRNA turnover and the mechanisms of action of the anti-cancer drug flavopiridol
Flavopiridol, a flavonoid currently in cancer clinical trials, inhibits cyclin-dependent kinases (CDKs) by competitively blocking their ATP-binding pocket. However, the mechanism of action of flavopiridol as a...
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Article
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling
Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the r...
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Article
Building lymphochip-computational algorithms for selecting clones highly expressed in B cell cDNA libraries
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Analysis of gene expression in normal and malignant lymphocytes using the Lymphochip cDNA microarray
