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  1. Article

    Open Access

    Evolution of anti-modified protein antibody responses can be driven by consecutive exposure to different post-translational modifications

    Besides anti-citrullinated protein antibodies (ACPA), rheumatoid arthritis patients (RA) often display autoantibody reactivities against other post-translationally modified (PTM) proteins, more specifically ca...

    M. Volkov, A. S. B. Kampstra, K. A. van Schie, A. Kawakami… in Arthritis Research & Therapy (2021)

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  2. Article

    Open Access

    Immunoprofiling of early, untreated rheumatoid arthritis using mass cytometry reveals an activated basophil subset inversely linked to ACPA status

    Autoantibody production is a hallmark of rheumatoid arthritis (RA). Anti-citrullinated protein antibodies (ACPA) are highly disease-specific, and their presence is associated with more severe disease and poor ...

    H. Koppejan, M. Hameetman, G. Beyrend, V. van Unen… in Arthritis Research & Therapy (2021)

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  3. Article

    Open Access

    Inflammation functions as a key mediator in the link between ACPA and erosion development: an association study in Clinically Suspect Arthralgia

    Anti-citrullinated protein antibodies (ACPA) are associated with more severe joint erosions in rheumatoid arthritis (RA), but the underlying mechanism is unclear. Recent in vitro and murine studies indicate th...

    R. M. ten Brinck, R. E. M. Toes… in Arthritis Research & Therapy (2018)

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  4. No Access

    Article

    Inflammatory genes TNFα and IL6 display no signs of increased H3K4me3 in circulating monocytes from untreated rheumatoid arthritis patients

    Innate immune cells, such as monocytes, can adopt a long-lasting pro-inflammatory phenotype, a phenomenon called ‘trained immunity’. In trained immunity, increased cytokine levels of genes, like interleukin (I...

    T C Messemaker, H M M Mikkers, T W Huizinga, R E M Toes… in Genes & Immunity (2017)

  5. No Access

    Article

    A novel long non-coding RNA in the rheumatoid arthritis risk locus TRAF1-C5 influences C5 mRNA levels

    Long non-coding RNAs (lncRNAs) can regulate the transcript levels of genes in the same genomic region. These locally acting lncRNAs have been found deregulated in human disease and some have been shown to harb...

    T C Messemaker, M Frank-Bertoncelj, R B Marques, A Adriaans, A M Bakker… in Genes & Immunity (2016)

  6. No Access

    Chapter

    Dendritic Cells and their Potential Implication in Pathology and Treatment of Rheumatoid Arthritis

    Dendritic cells (DC) are the professional antigen presenting cells that protect us against invading organisms. On the other hand, they uphold tolerance thereby avoiding the initiation of autoimmunity. In perfo...

    M. H. Wenink, W. Han, R. E. M. Toes, T. R. D. J. Radstake in Dendritic Cells (2009)

  7. No Access

    Article

    Characterization of an immuno ‘stealth’ derivative of the herpes simplex virus thymidine-kinase gene

    The cellular immune response against transgene-encoded neoantigens is a potential hurdle in gene therapy applications where long-term expression of transgenes is desired. Here a new optimized derivative of the he...

    M Ossevoort, A Zaldumbide, S J Cramer, E I H van der Voort… in Cancer Gene Therapy (2006)

  8. No Access

    Article

    Creation of immune ‘stealth’ genes for gene therapy through fusion with the Gly-Ala repeat of EBNA-1

    A major obstacle in gene-therapy protocols is T-cell-mediated destruction of transgene-expressing cells. Therefore new approaches are needed to prevent rapid clearance of transduced cells. We exploited the Gly...

    M Ossevoort, B M J Visser, D J M van den Wollenberg, E I H van der Voort… in Gene Therapy (2003)

  9. No Access

    Chapter

    Interplay Between Human Papillomaviruses and Dendritic Cells

    The design of the human papillomavirus (HPV) infection cycle is tightly fitted to the differentiation program of its natural host, the keratinocyte. This has important consequences for the role of antigen-pres...

    R. Offringa, A. de Jong, R. E. M. Toes… in Dendritic Cells and Virus Infection (2003)

  10. No Access

    Article

    The role of CD40 in peripheral T cell tolerance and immunity

    CD40 and CD40 ligand (CD40L) have been implicated as important molecules for the transformation of nonactivated antigen-presenting cells (APC) into cells that are potent inducers of cytotoxic T lymphocyte (CTL...

    L. Diehl, A.T. Den Boer, E.I.H. van der Voort… in Journal of Molecular Medicine (2000)

  11. No Access

    Article

    A dual function for CD40 agonists

    CD40 ligation serves as a powerful mediator of protective and therapeutic immunity against foreign invaders and cancer cells in vivo. A study now shows that agonistic antibodies against CD40 may also be useful in...

    E. Zanelli, R.E.M. Toes in Nature Medicine (2000)

  12. No Access

    Chapter

    Peptide Vaccination

    T Lymphocytes are capable of eradication of both virus- and non-virus induced tumor cells [1, 2]. The highly diverse repertoire of T cells and the increased knowledge of the recognized ligands make it possible...

    R. E. M. Toes, F. Ossendorp, E. I. H. van der Voort, E. Mengedé… in Gene Therapy (1999)

  13. No Access

    Chapter

    Vaccination Strategies to Induce T-Cell Immunity Against Tumours

    Effector T cells recognize immunogenic peptides that are presented on the cell membrane in the context of major histocompatibility complex (MHC) molecules. The vast majority of T cells consists of either CD8+ ...

    M. E. Ressing, R. E. M. Toes… in Cytokines and Growth Factors in Blood Tran… (1997)