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Longitudinal serum neurofilament light chain (sNfL) concentration relates to cognitive function in multiple sclerosis patients
Serum neurofilament light chain (sNfL) may be used as a biological marker of disease progression in multiple sclerosis (MS), although longitudinal studies correlating cognitive deficits to sNfL are limited.
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Article
Dealing with highly active multiple sclerosis after natalizumab-associated PML: could rituximab be of help?
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Article
Use of herbal remedies by multiple sclerosis patients: a nation-wide survey in Italy
Though recent progress in multiple sclerosis (MS) treatment is remarkable, numerous unmet needs remain to be addressed often inducing patients to look for complementary and alternative medicines (CAM), especia...
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Article
Natalizumab therapy of multiple sclerosis: recommendations of the Multiple Sclerosis Study Group—Italian Neurological Society
Three years after the introduction of natalizumab (NA) therapy for the second line treatment of relapsing-remitting multiple sclerosis (MS), Italian MS centers critically reviewed the scientific literature and...
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Article
The effect of natalizumab on cognitive function in patients with relapsing-remitting multiple sclerosis: preliminary results of a 1-year follow-up study
The objective of the study was to assess the natalizumab effect on the course of cognitive impairment in patients with relapsing-remitting multiple sclerosis (MS). Patients with active relapsing-remitting MS (n =...
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Article
Natalizumab efficacy on cognitive impairment in MS
We report follow-up data on the efficacy of natalizumab therapy on neuropsychological impairment on an italian MS group of 39 patients at 1 year and of 11 patients at 2 years. Results show a significant reduct...
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Article
Neuropsychological rehabilitation in adult multiple sclerosis
Neuropsychological impairment affects 40–65% of multiple sclerosis patients, mainly involving speed in information processing, attention, executive functions and memory. Deterioration occurs over time independ...
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Article
Ataxia with isolated vitamin E deficiency: neurological phenotype, clinical follow-up and novel mutations in TTPAgene in Italian families
Ataxia with vitamin E deficiency (AVED) is a rare autosomal recessive neurodegenerative disorder due to mutations in the alpha-tocopherol transfer protein (TTPA) gene on chromosome 8q13. AVED patients have progre...
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Article
The contribution of fast-FLAIR MRI for lesion detection in the brain of patients with systemic autoimmune diseases
Fast fluid-attenuated inversion recovery (fFLAIR) is more sensitive that conventional or fast spin echo T2-weighted magnetic resonance imaging (MRI) for detecting lesions in the brain of patients with ischemi...
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Article
Disease activity in multiple sclerosis studied by weekly triple-dose magnetic resonance imaging
This study assessed whether dysfunction of the blood-brain barrier is an obligatory early event in lesion formation in multiple sclerosis. Dual-echo and T1-weighted magnetic resonance imaging after the inject...
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Article
Two sisters with multiple sclerosis, lamellar ichthyosis, beta thalassaemia minor and a deficiency of factor VIII
Two of four sisters have multiple sclerosis (MS), lamellar ichthyosis, beta thalassaemia minor and a quantitative deficit of factor VIII-von Willebrand complex. The mother and the other sisters have only beta ...
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Article
Neuropsychological assessment in multiple sclerosis: a follow-up study with magnetic resonance imaging
Nineteen moderately impaired patients with clinically definite multiple sclerosis and an initially relapsing-remitting course were included in a neuropsychological and magnetic resonance imaging (MRI) follow-u...
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Failure to find HTLV I and HIV I serum antibodies in MS patients
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Myasthenic crisis during intravenous iodinated contrast medium injection