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7 Result(s)

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  1. Article

    Exploiting the architecture and the features of the microsporidian genomes to investigate diversity and impact of these parasites on ecosystems

    Fungal species play extremely important roles in ecosystems. Clustered at the base of the fungal kingdom are Microsporidia, a group of obligate intracellular eukaryotes infecting multiple animal lineages. Beca...

    E Peyretaillade, D Boucher, N Parisot, C Gasc, R Butler, J-F Pombert, E Lerat… in Heredity (2015)

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  2. Article

    Open Access

    A feasibility study testing four hypotheses with phase II outcomes in advanced colorectal cancer (MRC FOCUS3): a model for randomised controlled trials in the era of personalised medicine?

    Molecular characteristics of cancer vary between individuals. In future, most trials will require assessment of biomarkers to allocate patients into enriched populations in which targeted therapies are more li...

    T S Maughan, A M Meade, R A Adams, S D Richman, R Butler… in British Journal of Cancer (2014)

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  3. No Access

    Article

    CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments

    Three distinct promoters control the master regulator of major histocompatibility complex (MHC) class II expression, class II transactivator (CIITA), in a cell type-specific manner. Promoter I (pI) CIITA, expr...

    W M Zinzow-Kramer, A B Long, B A Youngblood, K M Rosenthal, R Butler… in Genes & Immunity (2012)

  4. Article

    Open Access

    A micro costing of NHS cancer genetic services

    This paper presents the first full micro costing of a commonly used cancer genetic counselling and testing protocol used in the UK. Costs were estimated for the Cardiff clinic of the Cancer Genetics Service in...

    G L Griffith, R Tudor-Edwards, J Gray, R Butler, C Wilkinson… in British Journal of Cancer (2005)

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  5. Article

    Two cases of acatalasia in Switzerland

    Es wird über 2 Fälle von Akatalasie, einem seltenen, bisher ausschliesslich bei Japanern beobachteten Enzym-Defekt, berichtet4.

    H. Aebi, J. P. Heiniger, R. Bütler, A. Hässig in Experientia (1961)

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  6. No Access

    Article

    Über einen möglichen Weg der Biosynthese der Carotinoide beiMucor hiemalis

    Our experiments up to now lead us to the hypothesis, that the biosynthesis of carotenoids may be started on acetyl-coenzyme A. The condensation of two molecules of acetyl-coenzyme A leads to acetoacetyl-coenzy...

    E. C. Grob, R. Bütler in Experientia (1955)

  7. No Access

    Article

    Über die Biosynthese des β-Carotins beiMucor hiemalis. Die Beteiligung der Essigsäure am Aufbau des Carotinmoleküls, untersucht mit Hilfe C14-markierter Essigsäure

    It has been demonstrated with labelled acetate, C14H3 . COONa, CH3-C14OONa), that the methyl groups of acetic acid form the methyl groups of the chain between the twoβ-jonone rings of theβ-carotene. The carboxyli...

    E. C. Grob, R. Bütler in Experientia (1954)