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  1. No Access

    Article

    Do NPM1 and FLT3-ITD mutations modify prognosis in patients treated with non-intensive regimens?

    FLT3-ITD and NPM1 mutations are key to defining the genetic risk profile of acute myeloid leukemia (AML). We aimed to assess the prognostic features of the FLT3-ITD and NPM1 mutations in old and/or unfit individu...

    E. U. Suárez, B. Boluda, E. Lavilla, M. Tormo, C. Botella, C. Gil in Annals of Hematology (2024)

  2. Article

    Open Access

    Correction: Large-scale real-life analysis of survival and usage of therapies in multiple myeloma

    N. Lopez-Muñoz, G. Hernández-Ibarburu, R. Alonso in Journal of Hematology & Oncology (2023)

  3. Article

    Open Access

    Large-scale real-life analysis of survival and usage of therapies in multiple myeloma

    Survival in multiple myeloma has improved significantly in recent years, especially in young patients. We reviewed the evolution of the survival of patients with MM in three groups based on age at MM diagnosis...

    N. Lopez-Muñoz, G. Hernández-Ibarburu, R. Alonso in Journal of Hematology & Oncology (2023)

  4. Article

    Open Access

    Outcomes and patterns of treatment in chronic myeloid leukemia, a global perspective based on a real-world data global network

    A. Sanz, R. Ayala, G. Hernández, N. Lopez, D. Gil-Alos, R. Gil in Blood Cancer Journal (2022)

  5. Article

    Open Access

    Impact of COVID-19 in patients with multiple myeloma based on a global data network

    The COVID-19 pandemic has represented a major cause of morbidity/mortality worldwide, overstressing health systems. Multiple myeloma (MM) patients show an increased risk for infections and they are expected to...

    J. Martinez-Lopez, G. Hernandez-Ibarburu, R. Alonso in Blood Cancer Journal (2021)

  6. No Access

    Article

    miR-146a rs2431697 identifies myeloproliferative neoplasm patients with higher secondary myelofibrosis progression risk

    Myelofibrosis (MF) occurs as part of the natural history of polycythemia vera (PV) and essential thrombocythemia (ET), and remarkably shortens survival. Although JAK2V617F and CALR allele burden are the main tran...

    F. Ferrer-Marín, A. B. Arroyo, B. Bellosillo, E. J. Cuenca, L. Zamora in Leukemia (2020)

  7. No Access

    Article

    Aortic stenosis prognosis in older patients: frailty is a strong marker of early congestive heart failure admissions

    Analyse which factors could influence in earlier hospitalizations for congestive heart failure in geriatric patients with degenerative aortic stenosis.

    M. Ramos, D. M. Quezada, R. Ayala, F. J. Gómez-Pavón in European Geriatric Medicine (2019)

  8. Article

    Open Access

    Analytical and clinical validation of a novel in-house deep-sequencing method for minimal residual disease monitoring in a phase II trial for multiple myeloma

    J Martinez-Lopez, B Sanchez-Vega, S Barrio, I Cuenca, Y Ruiz-Heredia, R Alonso in Leukemia (2017)

  9. No Access

    Article

    Rock magnetism in two loess–paleosol sequences in Córdoba, Argentina

    This work presents new rock magnetic results along two loess–paleosol profiles in nearby locations in Argentina. The main objective of this study is to compare the magnetic signals and mineral content of two ...

    S. Rouzaut, M. J. Orgeira, C. Vásquez, R. Ayala in Environmental Earth Sciences (2015)

  10. No Access

    Article

    Exome sequencing reveals novel and recurrent mutations with clinical impact in blastic plasmacytoid dendritic cell neoplasm

    Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a very rare disease that currently lacks genomic and genetic biomarkers to assist in its clinical management. We performed whole-exome sequencing (WES) o...

    J Menezes, F Acquadro, M Wiseman, G Gómez-López, R N Salgado in Leukemia (2014)

  11. No Access

    Article

    Microalgae from the mucus layer of two massive corals: more than sunken plankton

    The mucus of scleractinian corals harbors a variety of prokaryotic and eukaryotic microorganisms, but little is known about the eukaryotic fraction of this microbiota. In this study, a quantitative and qualita...

    F. Cavada, R. Ayala, L. Troccoli, J. J. Cruz-Motta in Marine Biology (2011)

  12. No Access

    Article

    Characterizing equivalent discrete Morse functions

    We get a characterization theorem for equivalent discrete Morse functions defined on simplicial complexes in terms of their gradient vector field. As a consequence, we also characterize them in the 1-dimension...

    R. Ayala, L.M. Fernández, J.A. Vilches in Bulletin of the Brazilian Mathematical Soc… (2009)

  13. No Access

    Chapter and Conference Paper

    A Study of DQE Dependence with Beam Quality, GE Senographe Essential Detector for Mammography

    This paper deals with the analysis of objective image quality parameters for the new GE Senographe Essential FFDM system at several beam qualities. The detector consists of an indirect conversion a-Si flat pan...

    R. García-Mollá, R. Linares, R. Ayala in World Congress on Medical Physics and Biom… (2009)

  14. No Access

    Chapter and Conference Paper

    MIQuaELa, Software for DQE Measuring in DIGITAL Radiography/Mammography

    Detective Quantum Efficiency (DQE) is considered the best metric for image quality evaluation in digital detectors. Unfortunately, it is not easy to assess without a specific software tool. The lack of a refer...

    R. Ayala, R. Linares, R. García-Mollá in World Congress on Medical Physics and Biom… (2009)

  15. Chapter and Conference Paper

    A Digital Lighting Function for Strong 26-Surfaces

    The goal of this paper is to generalize the notion of lighting function given in [3] in order to integrate strong 26-surfaces [5] into our framework for digital topology. In particular, the continuous analogue fo...

    R. Ayala, A. Quintero, E. Domínguez in Discrete Geometry for Computer Imagery (1999)

  16. No Access

    Article

    A Hahn-Mazurkiewicz Theorem for generalized Peano continua

    S. Mazurkiewicz remarked after his proof of the celebrated Hahn-Mazurkiewicz Theorem ([5]) that any generalized Peano continuum is the continuous image of the half-line \([0, \infty)\) ...

    R. Ayala, M.J. Chávez, A. Quintero in Archiv der Mathematik (1998)

  17. No Access

    Article

    On the planarity of infinite 2-complexes

    This paper is devoted to the problem of characterizing infinite planar polyhedra. We give two topological characterizations of planarity, and two others of proper planarity (embeddings with no accumulation poi...

    A. M’arquez, R. Ayala, A. Quintero in Abhandlungen aus dem Mathematischen Semina… (1997)

  18. Article

    Impact of Breast Feeding on the Number of Diarrheal Episodes and Nutritional Status in Children Less Than Six Months Old

    D Figueroa, J Centeno, G Aragín, C Brandán, J Malo, Lee R Cama in Pediatric Research (1997)

  19. Chapter and Conference Paper

    Digital lighting functions

    In this paper a notion of lighting function is introduced as an axiomatized formalization of the “face membership rules” suggested by Kovalevsky. These functions are defined in the context of the framework for...

    R. Ayala, E. Domínguez, A. R. Francés in Discrete Geometry for Computer Imagery (1997)

  20. Chapter and Conference Paper

    Determining the components of the complement of a Digital (n−1)-manifold in ℤn

    The goal of this paper is to determine the components of the complement of digital manifolds in the standard cubical decomposition of Euclidean spaces for arbitrary dimensions. Our main result generalizes the ...

    R. Ayala, E. Domínguez, A. R. Francés in Discrete Geometry for Computer Imagery (1996)

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