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Article
Open AccessIntroduction of an Alcohol-Related Electronic Screening and Brief Intervention (eSBI) Program to Reduce Hazardous Alcohol Consumption in Namibia’s Antiretroviral Treatment (ART) Program
Alcohol is the most widely abused substance in Namibia and is associated with poor adherence and retention in care among people on antiretroviral therapy (ART). Electronic screening and brief interventions (eS...
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Article
Open AccessA feasibility study testing four hypotheses with phase II outcomes in advanced colorectal cancer (MRC FOCUS3): a model for randomised controlled trials in the era of personalised medicine?
Molecular characteristics of cancer vary between individuals. In future, most trials will require assessment of biomarkers to allocate patients into enriched populations in which targeted therapies are more li...
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Article
Open AccessOxaliplatin/capecitabine vs oxaliplatin/infusional 5-FU in advanced colorectal cancer: the MRC COIN trial
COIN compared first-line continuous chemotherapy with the same chemotherapy given intermittently or with cetuximab in advanced colorectal cancer (aCRC).
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Article
Outcome of sliding inguinal hernia repair
Sliding inguinal hernias represent a small proportion of inguinal hernias but become more common with advancing age. The most recent review is based on a series published over 50 years ago. There are, however,...
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Article
Open AccessToxicity associated with combination oxaliplatin plus fluoropyrimidine with or without cetuximab in the MRC COIN trial experience
We present the preliminary toxicity data from the MRC COIN trial, a phase III randomised controlled trial of first-line therapy in advanced colorectal cancer, with particular reference to the addition of cetux...
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Article
Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia
The orphan G protein-coupled receptor 78 (GPR78) gene lies within a region of chromosome 4p where we have previously shown linkage to bipolar affective disorder (BPAD) in a large Scottish family. GPR78 was screen...
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Chapter and Conference Paper
The Special Suitability of Inbred Syrian Hamsters for Carcinogenesis Testing
The objective of this work is the development of a more sensitive bioassay model of carcinogenesis than is available in the currently used rats and mice, and one which would have a minimal incidence of spontan...
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Chapter
Coordinated Design of Radioisotope Laboratories
Recent advances in the use of radioisotopes as a research tool have broadened the scope of the field and have created the need for specially designed laboratories to handle more hazardous operations. Although ...
